Literature summary for 3.4.17.2 extracted from

Fernandez, D.; Pallares, I.; Vendrell, J.; Aviles, F.X.
Progress in metallocarboxypeptidases and their small molecular weight inhibitors (2010), Biochimie, 92, 484-500.

Search for more literature for 3.4.17.2

Inhibitors

Inhibitors	Comment	Organism	Structure
(R)-2-(3-guanidinophenyl)-3-mercaptopropanoic acid	-	Sus scrofa
(R)-2-guanidino-3-mercaptopropanoic acid	-	Sus scrofa
(S)-2-(2-((S)-1-carboxy-2-(1H-imidazol-5-yl)ethylamino)ethylamino)-5-guanidinopentanoic acid	IC50: 17 microgram/ml	Sus scrofa
(S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid	-	Sus scrofa
2-(2-chloro-5-guanidinophenyl)-3-mercaptopropanoic acid	-	Sus scrofa
2-(2-guanidinoethylthio)succinic acid	-	Sus scrofa
2-(3-guanidinophenyl)-3-mercaptopropanoic acid	-	Sus scrofa
2-(4-(furan-2-ylmethyl)-5-(4-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)-1-(thiophen-2-yl)ethanone	-	Sus scrofa
2-benzyl-3-mercaptopropanoic acid	-	Sus scrofa
5-guanidino-2-(mercaptomethyl)pentanoic acid	-	Sus scrofa
benzamidine	-	Sus scrofa
N-(3-chlorophenyl)-4-((5-(3-methoxybenzylthio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine	-	Sus scrofa
N-[[di(propan-2-yl)amino]-[3-(4-methoxyphenyl)-2-trimethylsilyloxiran-2-yl]phosphinothioyl]-N-propan-2-ylpropan-2-amine	-	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	P09955	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Sus scrofa	-

Synonyms

Synonyms	Comment	Organism
carboxypeptidase B	-	Sus scrofa

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000042	-	5-guanidino-2-(mercaptomethyl)pentanoic acid	-	Sus scrofa
0.000002	-	2-(3-guanidinophenyl)-3-mercaptopropanoic acid	-	Sus scrofa
0.000007	-	2-(2-chloro-5-guanidinophenyl)-3-mercaptopropanoic acid	-	Sus scrofa
0.000034	-	2-(2-guanidinoethylthio)succinic acid	-	Sus scrofa
0.000206	-	(S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid	-	Sus scrofa
0.0012	-	N-(3-chlorophenyl)-4-((5-(3-methoxybenzylthio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine	-	Sus scrofa
0.003	-	N-[[di(propan-2-yl)amino]-[3-(4-methoxyphenyl)-2-trimethylsilyloxiran-2-yl]phosphinothioyl]-N-propan-2-ylpropan-2-amine	-	Sus scrofa
0.004	-	2-(2-guanidinoethylthio)succinic acid	-	Sus scrofa
0.163	-	2-benzyl-3-mercaptopropanoic acid	-	Sus scrofa
5	-	benzamidine	-	Sus scrofa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000002	-	-	Sus scrofa	(R)-2-(3-guanidinophenyl)-3-mercaptopropanoic acid
0.000024	-	-	Sus scrofa	2-(4-(furan-2-ylmethyl)-5-(4-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)-1-(thiophen-2-yl)ethanone
0.0023	-	-	Sus scrofa	(R)-2-guanidino-3-mercaptopropanoic acid

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Release 2023.1 (January 2023)