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Literature summary for 3.4.17.1 extracted from

  • Pejler, G.; Knight, S.D.; Henningsson, F.; Wernersson, S.
    Novel insights into the biological function of mast cell carboxypeptidase A (2009), Trends Immunol., 30, 401-408.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
8-hydroxyquinoline
-
Homo sapiens
EDTA
-
Homo sapiens
potato carboxypeptidase inhibitor
-
Homo sapiens
SR48692
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule MC-CPA is a dominant protein component of the mast cell granule Homo sapiens 30141
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent exoprotease Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35780
-
mature enzyme after cleavage of the signal- and activation peptides Homo sapiens
36000
-
fully processed form of MC-CPA, SDS-PAGE Homo sapiens
48730
-
calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
?
-
?
apolipoprotein B + H2O Homo sapiens
-
?
-
?
endothelin-1 + H2O Homo sapiens
-
?
-
?
kinetensin + H2O Homo sapiens
-
?
-
?
neuromedin N + H2O Homo sapiens
-
?
-
?
neurotensin + H2O Homo sapiens
-
?
-
?
sarafotoxin 6b + H2O Homo sapiens
-
?
-
?
snake venom toxin + H2O Homo sapiens
-
?
-
?
vasoconstrictive factor endothelin 1 + H2O Homo sapiens
-
?
-
?
xenopsin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell the expression of human MC-CPA seems to be restricted to the MCTC subclass Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens ?
-
?
apolipoprotein B + H2O
-
Homo sapiens ?
-
?
endothelin-1 + H2O
-
Homo sapiens ?
-
?
kinetensin + H2O
-
Homo sapiens ?
-
?
neuromedin N + H2O
-
Homo sapiens ?
-
?
neurotensin + H2O
-
Homo sapiens ?
-
?
sarafotoxin 6b + H2O
-
Homo sapiens ?
-
?
snake venom toxin + H2O
-
Homo sapiens ?
-
?
vasoconstrictive factor endothelin 1 + H2O
-
Homo sapiens ?
-
?
xenopsin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
carboxypeptidase a
-
Homo sapiens
MC-CPA
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 9
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens MC-CPA gene expression is about 2fold upregulated by bacterial lipopolysaccharide up

General Information

General Information Comment Organism
physiological function MC-CPA plays a role in regulating innate immunity responses, including the degradation of harmful substances such as the vasoconstrictive factor endothelin 1 and snake venomtoxins Homo sapiens