Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-2-benzyl-3-nitropropanoic acid | X-ray crystallography discloses that the nitro group well mimics the transition state occurred in the hydrolysis catalyzed by CPA, that is, an O,O'-bidentate coordination to the zinc ion and the two respective hydrogen bonds with Glu-270 and Arg-127. Because the nitro group is a planar species, (R)-2-benzyl-3-nitropropanoic acid is as a pseudo-transition-state analog inhibitor against CPA | Bos taurus | |
(RS)-2-benzyl-3-nitropropanoic acid | - |
Bos taurus | |
(RS)-2-isobutyl-3-nitropropanoic acid | - |
Bos taurus | |
(S)-2-benzyl-3-nitropropanoic acid | - |
Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
O-(trans-p-chlorocinnamoyl)-L-beta-phenyllactate + H2O | - |
Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxypeptidase a | - |
Bos taurus |
CPA | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00015 | - |
(R)-2-benzyl-3-nitropropanoic acid | - |
Bos taurus | |
0.00015 | - |
2-benzyl-3-nitropropanoic acid | - |
Bos taurus | |
0.00079 | - |
(RS)-2-benzyl-3-nitropropanoic acid | - |
Bos taurus | |
0.002 | - |
(RS)-2-isobutyl-3-nitropropanoic acid | - |
Bos taurus | |
0.068 | - |
(S)-2-benzyl-3-nitropropanoic acid | - |
Bos taurus |