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Literature summary for 3.4.17.1 extracted from

  • Park, J.D.; Kim, D.H.
    Cysteine derivatives as inhibitors for carboxypeptidase A: synthesis and structure-activity relationships (2002), J. Med. Chem., 45, 911-918.
    View publication on PubMed
Search for more literature for 3.4.17.1

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-mercapto-3-phenylacrylic acid
-
 Bos taurus
(2E)-2-mercapto-4-phenylbut-2-enoic acid
-
 Bos taurus
(2E)-2-mercapto-5-phenylpent-2-enoic acid
-
 Bos taurus
(R)-N-benzylcysteine
-
 Bos taurus
(R)-N-cyclohexylcysteine
-
 Bos taurus
(R)-N-isopropylcysteine
-
 Bos taurus
(R)-N-phenethylcysteine
-
 Bos taurus
(S)-N-benzylcysteine
-
 Bos taurus
(S)-N-cyclohexylcysteine
-
 Bos taurus
(S)-N-isopropylcysteine
-
 Bos taurus
(S)-N-phenethylcysteine
-
 Bos taurus
anilino(mercapto)acetic acid
-
 Bos taurus
D-Cys
-
 Bos taurus
L-Cys
-
 Bos taurus
mercapto(methylamino)acetic acid
-
 Bos taurus
rac-2-(mercaptomethyl)-3-cyclohexylpropanoic acid
-
 Bos taurus
rac-2-(mercaptomethyl)-4-methylpentanoic acid
-
 Bos taurus
rac-2-(mercaptomethyl)-6-phenylhexanoic acid
-
 Bos taurus
rac-N-(1-naphthylmethyl)cysteine
-
 Bos taurus
rac-N-(cyclohexylmethyl)cysteine
-
 Bos taurus
rac-N-(p-methoxy)benzylcysteine
-
 Bos taurus
rac-N-benzyl-N-methylcysteine
-
 Bos taurus
rac-N-benzylcysteine
-
 Bos taurus
rac-N-cyclohexylcysteine
-
 Bos taurus
rac-N-ethylcysteine
-
 Bos taurus
rac-N-isobutylcysteine
-
 Bos taurus
rac-N-isopropylcysteine
-
 Bos taurus
rac-N-phenethylcysteine
-
 Bos taurus
rac-N-phenylpropylcysteine
-
 Bos taurus
rac-N-propylcysteine
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-L-Phe + H2O
-
 Bos taurus hippuric acid + Phe
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00001
-
 (2E)-2-mercapto-3-phenylacrylic acid pH 7.5, 25°C Bos taurus
0.000055
-
 (S)-N-phenethylcysteine pH 7.5, 25°C Bos taurus
0.000065
-
 rac-N-phenethylcysteine pH 7.5, 25°C Bos taurus
0.00016
-
 rac-2-(mercaptomethyl)-4-methylpentanoic acid pH 7.5, 25°C Bos taurus
0.00019
-
 (S)-N-benzylcysteine pH 7.5, 25°C Bos taurus
0.00027
-
 rac-N-benzylcysteine pH 7.5, 25°C Bos taurus
0.00056
-
 (S)-N-isopropylcysteine pH 7.5, 25°C Bos taurus
0.00061
-
 (R)-N-phenethylcysteine pH 7.5, 25°C Bos taurus
0.00081
-
 rac-N-(1-naphthylmethyl)cysteine pH 7.5, 25°C Bos taurus
0.00085
-
 rac-N-(p-methoxy)benzylcysteine pH 7.5, 25°C Bos taurus
0.0011
-
 rac-N-isopropylcysteine pH 7.5, 25°C Bos taurus
0.0013
-
 rac-N-phenylpropylcysteine pH 7.5, 25°C Bos taurus
0.0013
-
 rac2-(mercaptomethyl)-6-phenylhexanoic acid pH 7.5, 25°C Bos taurus
0.00135
-
 (2E)-2-mercapto-5-phenylpent-2-enoic acid pH 7.5, 25°C Bos taurus
0.0014
-
 rac-N-ethylcysteine pH 7.5, 25°C Bos taurus
0.0021
-
 (2E)-2-mercapto-4-phenylbut-2-enoic acid pH 7.5, 25°C Bos taurus
0.0023
-
 D-Cys pH 7.5, 25°C Bos taurus
0.00235
-
 rac-2-(mercaptomethyl)-3-cyclohexylpropanoic acid pH 7.5, 25°C Bos taurus
0.0024
-
 mercapto(methylamino)acetic acid pH 7.5, 25°C Bos taurus
0.0029
-
 (R)-N-isopropylcysteine pH 7.5, 25°C Bos taurus
0.0029
-
 (S)-N-cyclohexylcysteine pH 7.5, 25°C Bos taurus
0.0055
-
 anilino(mercapto)acetic acid
-
 Bos taurus
0.0056
-
 rac-N-propylcysteine pH 7.5, 25°C Bos taurus
0.0075
-
 rac-N-isobutylcysteine pH 7.5, 25°C Bos taurus
0.0079
-
 (R)-N-cyclohexylcysteine pH 7.5, 25°C Bos taurus
0.0094
-
 rac-N-(cyclohexylmethyl)cysteine pH 7.5, 25°C Bos taurus
0.0096
-
 rac-N-cyclohexylcysteine pH 7.5, 25°C Bos taurus
0.012
-
 rac-N-benzyl-N-methylcysteine pH 7.5, 25°C Bos taurus
0.033
-
 (R)-N-benzylcysteine pH 7.5, 25°C Bos taurus
0.35
-
 L-Cys pH 7.5, 25°C Bos taurus