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Literature summary for 3.4.16.5 extracted from

  • Yoshida, T.; Kadota, Y.; Hitaoka, S.; Kori, E.; Horikawa, Y.; Taguchi, M.; Tsuji, D.; Hirokawa, T.; Chuman, H.; Itoh, K.
    Expression and molecular dynamics studies on effect of amino acid substitutions at Arg344 in human cathepsin A on the protein local conformation (2009), Biochim. Biophys. Acta, 1794, 1693-1699.
    View publication on PubMed
Search for more literature for 3.4.16.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in T-1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R344A the mutant shows about wild type cathepsin A activity Homo sapiens
R344D inactive mutant, the 54 kDa precursor/zymogen with the R344D substitution is not processed to the 32/20 kDa mature form with CathA activity Homo sapiens
R344E the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344G the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344I the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344K the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344M the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344N the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344P the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344Q the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
R344S the mutant shows about wild type cathepsin A activity Homo sapiens
R344V the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 mature enzyme, SDS-PAGE Homo sapiens
54000
-
 proenzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P10619
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
fibroblast cell line from a galactosialidosis patient transformed with simian virus-40-adenovirus recombinant Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-L-Phe-L-Leu + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe + L-Leu
-
 ?

Synonyms

Synonyms Comment Organism
carboxypeptidase Y
-
 Homo sapiens
CathA
-
 Homo sapiens
cathepsin A
-
 Homo sapiens
CPY
-
 Homo sapiens
EC 3.4.16.1 formerly Homo sapiens
lysosomal protective protein
-
 Homo sapiens