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Literature summary for 3.4.15.1 extracted from

  • Corvol, P.; Williams, T.A.; Soubrier, F.
    Peptidyl dipeptidase A: angiotensin I-converting enzyme (1995), Methods Enzymol., 248, 283-305.
    View publication on PubMed
Search for more literature for 3.4.15.1

Activating Compound

Activating Compound Comment Organism Structure
Cl-
-
 Homo sapiens
Cl- required for hydrolysis of angiotensin I, not required for hydrolysis of bradykinin Mammalia

Cloned(Commentary)

Cloned (Comment) Organism
somatic enzyme form Mus musculus
somatic enzyme form Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
9-[1-carboxy-3-(4-hydroxyphenyl)propylamino]octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepine-1-carboxylic acid
-
 Mammalia
captopril i.e. D-(3-mercapto-2-methylpropanoyl)-L-Pro Homo sapiens
captopril i.e. D-(3-mercapto-2-methylpropanoyl)-L-Pro Mammalia
captopril
-
 Rattus norvegicus
enaprilat
-
 Homo sapiens
enaprilat i.e. N-[(S)-1-carboxy-3-phenylpropyl]-Ala-Pro Mammalia
enaprilat
-
 Rattus norvegicus
lisinopril
-
 Homo sapiens
lisinopril i.e. N-[(S)-1-carboxy-3-phenylpropyl]-L-Lys-L-Pro Mammalia

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Mammalia
additional information
-
 additional information
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane anchored to plasma membrane, the bulk of its mass exposed at the extracellular surface of the cell Mammalia 16020
-
membrane inserted in plasma membrane via the carboxyl terminus Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc
-
 Homo sapiens
Zinc required Mammalia

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000 110000 germinal cells, germinal cells also contain an enzyme form of MW 150000-180000 Da, gel filtration Mammalia
150000 180000 somatic enzyme form in endothelial, epithelial, neuronal, and germinal cells, in germinal cells a second enzyme form of 90000-110000 Da exists, gel filtration Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens
-
 ?
-
 ?
additional information Rattus norvegicus
-
 ?
-
 ?
additional information Mammalia the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mammalia
-
 two ACE forms: a somatic form of MW 150000-180000 Da and a smaller isoform of MW 90009-110000 Da in germinal cells
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycoprotein Mammalia
side-chain modification glycoprotein Homo sapiens
side-chain modification glycoprotein Rattus norvegicus
side-chain modification somatic enzyme form contains 17 potential glycosylation sites but no Ser/Thr-rich region indicative of O-glycosylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
 Homo sapiens
-
endothelium vascular Mammalia
-
epithelium brush border of absorptive epithelia on the small intestine and the renal convoluted tubule Mammalia
-
germ
-
 Mammalia
-
kidney
-
 Mus musculus
-
kidney
-
 Homo sapiens
-
kidney
-
 Rattus norvegicus
-
lung
-
 Homo sapiens
-
lung
-
 Rattus norvegicus
-
macrophage
-
 Mammalia
-
monocyte
-
 Mammalia
-
neuron
-
 Mammalia
-
T-lymphocyte
-
 Mammalia
-
testis
-
 Mammalia
-
testis
-
 Homo sapiens
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Mammalia angiotensin II + His-Leu
-
 ?
angiotensin I + H2O
-
 Mus musculus angiotensin II + His-Leu
-
 ?
angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
beta-neoendorphin + H2O
-
 Mammalia ?
-
 ?
bradykinin + H2O
-
 Mammalia Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
bradykinin + H2O
-
 Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
bradykinin + H2O
-
 Rattus norvegicus Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
cholecystokinin-8 + H2O
-
 Mammalia ?
-
 ?
dynorphin + H2O
-
 Mammalia ?
-
 ?
hippuryl-Gly-Gly + H2O
-
 Mammalia hippuric acid + Gly-Gly
-
 ?
hippuryl-Gly-Gly + H2O
-
 Homo sapiens hippuric acid + Gly-Gly
-
 ?
hippuryl-His-Leu + H2O
-
 Homo sapiens hippuric acid + His-Leu
-
 ?
hippuryl-His-Leu + H2O
-
 Rattus norvegicus hippuric acid + His-Leu
-
 ?
Met5-enkephalin + H2O
-
 Mammalia Tyr-Gly-Gly + Phe-Met
-
 ?
Met5-enkephalin + H2O
-
 Homo sapiens Tyr-Gly-Gly + Phe-Met
-
 ?
Met5-enkephalin-Arg6-Gly7-Leu8 + H2O
-
 Mammalia Tyr-Gly-Gly-Phe-met-Arg + Gly-Leu
-
 ?
additional information
-
 Homo sapiens ?
-
 ?
additional information
-
 Rattus norvegicus ?
-
 ?
additional information the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes Mammalia ?
-
 ?
neurotensin + H2O
-
 Mammalia pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr + Ile-Leu
-
 ?
neurotensin + H2O
-
 Homo sapiens pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr + Ile-Leu
-
 ?