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Literature summary for 3.4.15.1 extracted from
- Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine (1986), Biochim. Biophys. Acta, 883, 361-372.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| captopril | - |
Homo sapiens |  |
| N-[1(S)-carboxy-5-aminopentyl]glycylglycine | weak competitive | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.062 | - |
angiotensin I | lung enzyme | Homo sapiens | |
| 0.076 | - |
angiotensin I | kidney enzyme | Homo sapiens | |
| 1.7 | - |
hippuryl-His-Leu | enzyme from kidney | Homo sapiens | |
| 1.9 | - |
hippuryl-His-Leu | enzyme from lung | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | maximal activation at 620 mM NaCl, hydrolysis of hippuryl-His-Leu | Homo sapiens | |
| NaCl | maximal activation at 20 mM NaCl, hydroysis of angiotensin I | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 160000 | - |
x * 160000, lung and kidney enzyme, SDS-PAGE with or without 1% 2-mercaptoethanol | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 88 | - |
kidney | Homo sapiens |
| 104 | - |
lung | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
| hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 160000, lung and kidney enzyme, SDS-PAGE with or without 1% 2-mercaptoethanol | Homo sapiens |
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