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Literature summary for 3.4.15.1 extracted from

  • Cushman, D.W.; Cheung, H.S.; Sabo, E.F.; Rubin, B.; Ondetti, M.A.
    Development of specific inhibitors of angiotensin I converting enzyme (kininase II) (1979), Fed. Proc., 38, 2778-2782.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
captopril competitive, of great value for use in chronic therapy of human hypertensive disease Homo sapiens
Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro therapeutical useful Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc contains zinc Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens may contribute to elevated blood pressure in hypertensive disease via conversion of angiotensin I to angiotensin II or inactivation of bradykinin ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin II + His-Leu
-
?
angiotensin I + H2O
-
Sus scrofa angiotensin II + His-Leu
-
?
bradykinin + H2O
-
Homo sapiens Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?
bradykinin + H2O
-
Sus scrofa Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
?
additional information may contribute to elevated blood pressure in hypertensive disease via conversion of angiotensin I to angiotensin II or inactivation of bradykinin Homo sapiens ?
-
?