Any feedback?
Literature summary for 3.4.15.1 extracted from
- N- versus C-domain selectivity of catalytic inactivation of human angiotensin converting enzyme by lisinopril-coupled transition metal chelates (2013), J. Med. Chem., 56, 9826-9836.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| lisinopril | - |
Homo sapiens |  |
| [CB-TE2A]1--lisinopril | - |
Homo sapiens | |
| [Co-DOTA]1--lisinopril | - |
Homo sapiens | |
| [Co-EDTA]1--lisinopril | - |
Homo sapiens | |
| [Co-GGH]0-lisinopril | - |
Homo sapiens | |
| [Co-NTA]0-lisinopril | - |
Homo sapiens | |
| [Cu-CB-TE2A]1+-lisinopril | - |
Homo sapiens | |
| [Cu-DOTA]1--lisinopril | - |
Homo sapiens | |
| [Cu-EDTA]1--lisinopril | - |
Homo sapiens | |
| [Cu-GGH]0-lisinopril | - |
Homo sapiens | |
| [Cu-NTA]0-lisinopril | - |
Homo sapiens | |
| [DOTA]1--lisinopril | - |
Homo sapiens | |
| [EDTA]3-lisinopril | - |
Homo sapiens | |
| [Fe-CB-TE2A]2+-lisinopril | - |
Homo sapiens | |
| [Fe-DOTA]0-lisinopril | - |
Homo sapiens | |
| [Fe-EDTA]0-lisinopril | - |
Homo sapiens | |
| [Fe-NTA]1+-lisinopril | - |
Homo sapiens | |
| [GGH]1+-lisinopril | - |
Homo sapiens | |
| [Ni-CB-TE2A]1+-lisinopril | - |
Homo sapiens | |
| [Ni-DOTA]1--lisinopril | - |
Homo sapiens | |
| [Ni-EDTA]1--lisinopril | - |
Homo sapiens | |
| [Ni-GGH]0-lisinopril | - |
Homo sapiens | |
| [Ni-NTA]0-lisinopril | - |
Homo sapiens | |
| [NTA]2-lisinopril | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0045 | - |
Mca-RPPGFSAFK(Dnp)-OH | pH 7.4, 37°C | Homo sapiens | |
| 0.012 | - |
Abz-LFK(Dnp)-OH | pH 7.4, 37°C | Homo sapiens | |
| 0.035 | - |
Abz-SDK(Dnp)P-OH | pH 7.4, 37°C | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Abz-LFK(Dnp)-OH + H2O | - |
Homo sapiens | Abz-Leu-Phe + N6-(2,4-dinitrophenyl)-L-lysine | - |
? | |
| Abz-SDK(Dnp)P-OH + H2O | - |
Homo sapiens | Abz-Ser-Asp + Lys(Dnp)-Pro | - |
? | |
| Mca-RPPGFSAFK(Dnp)-OH + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sACE-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3 | - |
Abz-SDK(Dnp)P-OH | pH 7.4, 37°C | Homo sapiens | |
| 20.33 | - |
Mca-RPPGFSAFK(Dnp)-OH | pH 7.4, 37°C | Homo sapiens | |
| 23 | - |
Abz-LFK(Dnp)-OH | pH 7.4, 37°C | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000001 | - |
lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00000012 | - |
[Co-NTA]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00000024 | - |
[Fe-NTA]1+-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00000026 | - |
[Ni-NTA]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00000031 | - |
[NTA]2-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00000033 | - |
[Cu-NTA]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000001 | - |
lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000008 | - |
[CB-TE2A]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000014 | - |
[Cu-CB-TE2A]1+-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000015 | - |
[Fe-CB-TE2A]2+-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000016 | - |
[Fe-EDTA]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000017 | - |
[Ni-CB-TE2A]1+-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000018 | - |
[CB-TE2A]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000023 | - |
[Ni-CB-TE2A]1+-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000027 | - |
[Co-GGH]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000028 | - |
[Cu-CB-TE2A]1+-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000029 | - |
[GGH]1+-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000033 | - |
[Ni-NTA]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000035 | - |
[Fe-NTA]1+-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000038 | - |
[Cu-NTA]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00004 | - |
[Co-NTA]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000057 | - |
[NTA]2-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0001 | - |
[Cu-GGH]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000102 | - |
[GGH]1+-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00011 | - |
[Ni-GGH]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00014 | - |
[EDTA]3-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00015 | - |
[Fe-EDTA]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.000189 | - |
[Co-GGH]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00023 | - |
[Cu-EDTA]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00029 | - |
[Cu-DOTA]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0003 | - |
[Co-DOTA]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00034 | - |
[DOTA]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00041 | - |
[Co-EDTA]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00042 | - |
[Fe-DOTA]0-lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00045 | - |
[Ni-DOTA]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00049 | - |
[Ni-EDTA]1--lisinopril | with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00054 | - |
[Fe-CB-TE2A]2+-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.00058 | - |
[EDTA]3-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.001 | - |
[Ni-GGH]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0017 | - |
[Cu-EDTA]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0018 | - |
[Cu-DOTA]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0019 | - |
[Cu-GGH]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0021 | - |
[Fe-DOTA]0-lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0022 | - |
[DOTA]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0023 | - |
[Co-DOTA]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0026 | - |
[Ni-EDTA]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0026 | - |
[Ni-DOTA]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | |
| 0.0027 | - |
[Co-EDTA]1--lisinopril | with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000021 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Co-NTA]0-lisinopril | |
| 0.00000025 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | lisinopril | |
| 0.00000044 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Fe-NTA]1+-lisinopril | |
| 0.00000047 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Ni-NTA]0-lisinopril | |
| 0.00000056 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [NTA]2-lisinopril | |
| 0.0000006 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Cu-NTA]0-lisinopril | |
| 0.0000015 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | lisinopril | |
| 0.000014 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [CB-TE2A]1--lisinopril | |
| 0.000023 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [CB-TE2A]1--lisinopril | |
| 0.000026 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Cu-CB-TE2A]1+-lisinopril | |
| 0.000028 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Fe-CB-TE2A]2+-lisinopril | |
| 0.00003 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Fe-EDTA]0-lisinopril | |
| 0.00003 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Ni-CB-TE2A]1+-lisinopril | |
| 0.000032 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Ni-CB-TE2A]1+-lisinopril | |
| 0.000036 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Cu-CB-TE2A]1+-lisinopril | |
| 0.000042 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Ni-NTA]0-lisinopril | |
| 0.000044 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Fe-NTA]1+-lisinopril | |
| 0.000048 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Cu-NTA]0-lisinopril | |
| 0.00005 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Co-GGH]0-lisinopril | |
| 0.000051 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Co-NTA]0-lisinopril | |
| 0.000054 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [GGH]1+-lisinopril | |
| 0.000073 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [NTA]2-lisinopril | |
| 0.00013 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [GGH]1+-lisinopril | |
| 0.00019 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Cu-GGH]0-lisinopril | |
| 0.00019 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Fe-EDTA]0-lisinopril | |
| 0.00021 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Ni-GGH]0-lisinopril | |
| 0.00024 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Co-GGH]0-lisinopril | |
| 0.000257 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [EDTA]3-lisinopril | |
| 0.00042 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Cu-EDTA]1--lisinopril | |
| 0.00053 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Cu-DOTA]1--lisinopril | |
| 0.00062 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Co-DOTA]1--lisinopril | |
| 0.000629 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [DOTA]1--lisinopril | |
| 0.00069 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Fe-CB-TE2A]2+-lisinopril | |
| 0.00074 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [EDTA]3-lisinopril | |
| 0.00076 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Co-EDTA]1--lisinopril | |
| 0.00078 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Fe-DOTA]0-lisinopril | |
| 0.00083 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Ni-DOTA]1--lisinopril | |
| 0.0009 | - |
with Abz-LFK(Dnp)-OH (C-domain), pH 7.4, 37°C | Homo sapiens | [Ni-EDTA]1--lisinopril | |
| 0.0013 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Ni-GGH]0-lisinopril | |
| 0.0021 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Cu-EDTA]1--lisinopril | |
| 0.0023 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Cu-GGH]0-lisinopril | |
| 0.0023 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Cu-DOTA]1--lisinopril | |
| 0.0027 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [DOTA]1--lisinopril | |
| 0.0027 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Fe-DOTA]0-lisinopril | |
| 0.0029 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Co-DOTA]1--lisinopril | |
| 0.0033 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Ni-DOTA]1--lisinopril | |
| 0.0034 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Co-EDTA]1--lisinopril | |
| 0.0034 | - |
with Abz-SDK(Dnp)P-OH (N-domain), pH 7.4, 37°C | Homo sapiens | [Ni-EDTA]1--lisinopril |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
