Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fosinopril | causes a significant decrease in plasminogen activator inhibitor 1, PAI-1, levels, probably by aldosterone escape | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Homo sapiens | - |
angiotensin II + His-Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Homo sapiens |
angiotensin-converting enzyme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ACE is responsible for degradation of bradykinin which is the most potent stimulus for tissue plasminogen activator secretion. The reaction product from angiotensin I cleavage, angiotensin II, has an important role on fibrinolytic balance causing release of plasminogen activator inhibitor 1 and consequently inhibits fibrinolysis | Homo sapiens |