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Literature summary for 3.4.15.1 extracted from

  • Lucero, H.A.; Kintsurashvili, E.; Marketou, M.E.; Gavras, H.
    Cell signaling, internalization, and nuclear localization of the angiotensin converting enzyme in smooth muscle and endothelial cells (2010), J. Biol. Chem., 285, 5555-5568.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Rattus norvegicus
-
-
additional information subcellular localization study, selective nuclear localization of ACE in smooth muscle cells and umbilical vein cells, HUVEC, may require the expression of specific protein receptors in these cells, overview. Mechanism of ACE endocytosis, overview Rattus norvegicus
-
-
nuclear envelope
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Rattus norvegicus 5635
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nucleus transcriptional regulation by exogenous ACE may involve its nuclear localization, nuclear localization of ACE is impaired by selective inhibitors of endocytosis Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Rattus norvegicus i.e. DRVYIHPFHL angiotensin II + His-Leu i.e. DRVYIHPF ?
bradykinin + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme, nucleus preparation, gel filtration Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Rattus norvegicus
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endothelial cell
-
Rattus norvegicus
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kidney
-
Rattus norvegicus
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smooth muscle cell from aorta, extracellular ACE binds to smooth muscle cells, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O i.e. DRVYIHPFHL Rattus norvegicus angiotensin II + His-Leu i.e. DRVYIHPF ?
bradykinin + H2O
-
Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
More ACE contains transactivation domains in its sequence Rattus norvegicus

Synonyms

Synonyms Comment Organism
ACE
-
Rattus norvegicus
angiotensin converting enzyme
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 7.9 assay at Rattus norvegicus

General Information

General Information Comment Organism
physiological function ACE catalyzes the extracellular formation of angiotensin II, and degradation of bradykinin, thus regulating blood pressure and renal handling of electrolytes. ACE added to smooth muscle cells resultes in transcriptional stimulation of the genes of bradykinin receptors B1 and B2. ACE enhances the activation of platelet-derived growth factor receptor beta signaling pathway Rattus norvegicus