Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Rattus norvegicus | - |
- |
additional information | subcellular localization study, selective nuclear localization of ACE in smooth muscle cells and umbilical vein cells, HUVEC, may require the expression of specific protein receptors in these cells, overview. Mechanism of ACE endocytosis, overview | Rattus norvegicus | - |
- |
nuclear envelope | - |
Rattus norvegicus | 5635 | - |
nucleus | transcriptional regulation by exogenous ACE may involve its nuclear localization, nuclear localization of ACE is impaired by selective inhibitors of endocytosis | Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Rattus norvegicus | i.e. DRVYIHPFHL | angiotensin II + His-Leu | i.e. DRVYIHPF | ? | |
bradykinin + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme, nucleus preparation, gel filtration | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Rattus norvegicus | - |
endothelial cell | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
smooth muscle cell | from aorta, extracellular ACE binds to smooth muscle cells, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | i.e. DRVYIHPFHL | Rattus norvegicus | angiotensin II + His-Leu | i.e. DRVYIHPF | ? | |
bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | ACE contains transactivation domains in its sequence | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Rattus norvegicus |
angiotensin converting enzyme | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 7.9 | assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | ACE catalyzes the extracellular formation of angiotensin II, and degradation of bradykinin, thus regulating blood pressure and renal handling of electrolytes. ACE added to smooth muscle cells resultes in transcriptional stimulation of the genes of bradykinin receptors B1 and B2. ACE enhances the activation of platelet-derived growth factor receptor beta signaling pathway | Rattus norvegicus |