Any feedback?
Literature summary for 3.4.15.1 extracted from
- Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system (2010), Br. J. Pharmacol., 159, 1672-1680.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| perindopril | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | ACE is expressed in osteoblasts and hypertrophic chondrocytes in the periosteal callus during fracture healing, accompanied by expression of the angiotensin type-1 and type-2 receptors | Mus musculus | - |
| chondrocyte | - |
Mus musculus | - |
| osteoblast | - |
Mus musculus | - |
| osteoclast | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACE | - |
Mus musculus |
| angiotensin-converting enzyme | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ACE is part of the renin-angiotensin system, RAS, that regulates blood pressure and electrolyte homeostasis, and is involved in regulating regeneration, cell growth, apoptosis, inflammation and angiogenesis, expression and function of the key RAS component ACE during fracture healing, overview. ACE is important in bone remodelling | Mus musculus |
| physiological function | key enzyme of the renin-angiotensin system, a circulating endocrine system regulating blood pressure and electrolyte homeostasis. Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation in a murine femur fracture model, overview | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
