Literature summary for 3.4.15.1 extracted from

Kohlstedt, K.; Gershome, C.; Friedrich, M.; Mueller-Esterl, W.; Alhenc-Gelas, F.; Busse, R.; Fleming, I.
Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells (2006), Mol. Pharmacol., 69, 1725-1732.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ramiprilat	the ACE inhibitor-induced dimerization of angiotensin-converting enzyme, via the C domain of the enzyme, represents the initial step in the angiotensin-converting enzyme signaling pathway that involves the activation of the JNK/c-Jun pathway and leads to changes in endothelial cell gene expression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P12821	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical vein endothelial cell	stably overexpressing human somatic ACE	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
somatic ACE	-	Homo sapiens

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Release 2023.1 (January 2023)