Application | Comment | Organism |
---|---|---|
medicine | purified human ACE converts amyloid beta-protein1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas. The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease | Mus musculus |
medicine | purified human ACE converts amyloid beta-protein1-42 to amyloid beta-protein1-40. ACE regulates Abeta142/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta140 and degrading Abetas. The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
captopril | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
amyloid beta-protein 1-42 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta-protein 1-42 + H2O | Homo sapiens | angiotensin-converting enzyme converts amyloid beta-protein 1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas.The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease | amyloid beta-protein 1-420 + ? | - |
? | |
amyloid beta-protein 1-42 + H2O | Mus musculus | angiotensin-converting enzyme converts amyloid beta-protein1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas. The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease | amyloid beta-protein 1-420 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta-protein 1-42 + H2O | angiotensin-converting enzyme converts amyloid beta-protein 1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas.The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease | Homo sapiens | amyloid beta-protein 1-420 + ? | - |
? | |
amyloid beta-protein 1-42 + H2O | angiotensin-converting enzyme converts amyloid beta-protein1-42 to amyloid beta-protein1-40. ACE regulates Abeta1-42/Abeta1-40 ratio in vivo by converting secreted Abeta1-42 to Abeta1-40 and degrading Abetas. The upregulation of ACE activity can be a novel therapeutic strategy for Alzheimers disease | Mus musculus | amyloid beta-protein 1-420 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
angiotensin-converting enzyme | - |
Mus musculus |
angiotensin-converting enzyme | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.2 | - |
amyloid beta-protein 1-42 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
- |
Homo sapiens | captopril |