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Literature summary for 3.4.15.1 extracted from

  • Redelinghuys, P.; Nchinda, A.T.; Chibale, K.; Sturrock, E.D.
    Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling (2006), Biol. Chem., 387, 461-466.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
1-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-proline
-
 Homo sapiens
1-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-proline
-
 Homo sapiens
lisinopril
-
 Homo sapiens
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-phenylalanine
-
 Homo sapiens
N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-tryptophan
-
 Homo sapiens
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-phenylalanine
-
 Homo sapiens
N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-tryptophan
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P12821 recombinant ACE construct tACEDELTA36NJ
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-His-Leu + H2O
-
 Homo sapiens benzyloxycarbonyl-Phe + His-Leu
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000051
-
 lisinopril inhibition of C-domain Homo sapiens
0.0001315
-
 lisinopril inhibition of N-domain Homo sapiens
0.0008
-
 N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-tryptophan inhibition of C-domain Homo sapiens
0.0018
-
 1-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-proline inhibition of C-domain Homo sapiens
0.0133
-
 N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-tryptophan inhibition of N-domain Homo sapiens
0.0237
-
 N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-phenylalanine inhibition of C-domain Homo sapiens
0.0336
-
 1-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-proline inhibition of N-domain Homo sapiens
0.043
-
 N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-phenylalanine inhibition of N-domain Homo sapiens
0.0452
-
 1-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-proline inhibition of N-domain Homo sapiens
0.0843
-
 N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-phenylalanine inhibition of N-domain Homo sapiens
0.1435
-
 1-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-proline inhibition of C-domain Homo sapiens
0.1957
-
 N-[(5S)-4-oxo-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl]-L-tryptophan inhibition of N-domain Homo sapiens
0.3129
-
 N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-phenylalanine inhibition of C-domain Homo sapiens
0.3813
-
 N-[(5S)-5-[(tert-butoxycarbonyl)amino]-4-oxo-6-phenylhexanoyl]-L-tryptophan inhibition of C-domain Homo sapiens