Inhibitors | Comment | Organism | Structure |
---|---|---|---|
captopril | - |
Bos taurus | |
lisinopril | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the two active sites within bovine lung enzyme exhibits strong negative cooperativity | Bos taurus | |
0.005 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
0.008 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro | pH 7.5, 25°C, enzyme from lung | Bos taurus | |
0.008 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro | pH 7.5, 25°C, N-domain from lung enzyme | Bos taurus | |
0.05 | - |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg | pH 7.5, 25°C, enzyme from lung | Bos taurus | |
0.05 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Ala | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
0.05 | - |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg | pH 7.5, 25°C, N-domain from lung enzyme | Bos taurus | |
0.12 | - |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
0.13 | - |
benzyloxycarbonyl-Phe-His-Leu | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
0.14 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys | pH 7.5, 25°C, N-domain from lung enzyme | Bos taurus | |
0.15 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys | pH 7.5, 25°C, enzyme from lung | Bos taurus | |
0.17 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
0.5 | - |
N-(3-(2-furyl)acryloyl)-Phe-Gly-Gly | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
0.6 | - |
N-benzyloxycarbonyl-L-Phe-L-His-L-Leu | pH 7.5, 25°C, enzyme from testis | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Bos taurus | - |
testis | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-His-Leu + H2O | - |
Bos taurus | ? | - |
? | |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Ala + H2O | - |
Bos taurus | 2-furylacrylic acid + Phe-Ala-Ala | - |
? | |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys + H2O | - |
Bos taurus | 2-furylacrylic acid + Phe-Ala-Lys | - |
? | |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro + H2O | - |
Bos taurus | 2-furylacrylic acid + Phe-Ala-Pro | - |
? | |
N-(3-(2-furyl)acryloyl)-Phe-Gly-Gly + H2O | - |
Bos taurus | 2-furylacrylic acid + Phe-Gly-Gly | - |
? | |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg + H2O | - |
Bos taurus | 2-furylacrylic acid + Phe-Phe-Arg | - |
? | |
N-benzyloxycarbonyl-L-Phe-L-His-L-Leu + H2O | - |
Bos taurus | N-benzyloxycarbonyl-L-Phe + L-His-L-Leu | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the two active sites within bovine lung enzyme exhibitsstrong negative cooperativity | Bos taurus | |
8 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro | pH 7.5, 25°C, N-domain from lung enzyme | Bos taurus | |
12 | - |
N-benzyloxycarbonyl-L-Phe-L-His-L-Leu | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
19 | - |
benzyloxycarbonyl-Phe-His-Leu | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
30 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro | pH 7.5, 25°C, enzyme from lung | Bos taurus | |
35 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys | pH 7.5, 25°C, N-domain from lung enzyme | Bos taurus | |
45 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Pro | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
45 | - |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg | pH 7.5, 25°C, N-domain from lung enzyme | Bos taurus | |
54 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys | pH 7.5, 25°C, enzyme from lung | Bos taurus | |
76 | - |
N-(3-(2-furyl)acryloyl)-Phe-Phe-Arg | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
85 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Lys | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
178 | - |
N-(3-(2-furyl)acryloyl)-Phe-Ala-Ala | pH 7.5, 25°C, enzyme from testis | Bos taurus | |
260 | - |
N-(3-(2-furyl)acryloyl)-Phe-Gly-Gly | pH 7.5, 25°C, enzyme from testis | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000012 | - |
lisinopril | pH 7.5, 37°C, enzyme from testis | Bos taurus | |
0.00000018 | - |
lisinopril | pH 7.5, 37°C, enzyme from lung | Bos taurus | |
0.0000002 | - |
lisinopril | pH 7.5, 37°C, N-domain from lung enzyme | Bos taurus | |
0.0000005 | - |
captopril | pH 7.5, 37°C, N-domain from lung enzyme | Bos taurus | |
0.0000006 | - |
captopril | pH 7.5, 37°C, enzyme from lung | Bos taurus | |
0.000009 | - |
captopril | pH 7.5, 37°C, enzyme from testis | Bos taurus |