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Literature summary for 3.4.13.19 extracted from

  • Habib, G.M.; Shi, Z.Z.; Cuevas, A.A.; Lieberman, M.W.
    Identification of two additional members of the membrane-bound dipeptidase family (2003), FASEB J., 17, 1313-1315.
    View publication on PubMed
Search for more literature for 3.4.13.19

Cloned(Commentary)

Cloned (Comment) Organism
expression of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3 in COS cells Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 leukotriene D4 membrane-bound dipeptidase-2 Mus musculus
0.01
-
 leukotriene D4 membrane-bound dipeptidase-1 Mus musculus
0.111
-
 beta-lactam membrane-bound dipeptidase-1 Mus musculus
0.45
-
 L-cystinyl-bis-Gly membrane-bound dipeptidase-1 Mus musculus
2.5
-
 L-cystinyl-bis-Gly membrane-bound dipeptidase-3 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound dipeptidase-1, membrane-bound dipeptidase-2, membrane-bound dipeptidase-3 Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 membrane-bound dipeptidase-1, membrane-bound dipeptidase-2, membrane-bound dipeptidase-3
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3 are membrane-bound through a glycosylphosphatidyl-inositol linkage Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
heart high expression of membrane-bound dipeptidase-1 and membrane-bound dipeptidase-2, expression of membrane-bound dipeptidase-3 is not detectable Mus musculus
-
kidney high expression of membrane-bound dipeptidase-1, expression of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3 is not detectable Mus musculus
-
liver expression of membrane-bound dipeptidase-3 is not detectable, weak expression of membrane-bound dipeptidase-1 and membrane-bound dipeptidase-2 Mus musculus
-
lung high expression of membrane-bound dipeptidase-1 and membrane-bound dipeptidase-2, expression of membrane-bound dipeptidase-3 is not detectable Mus musculus
-
additional information no expression of membrane-bound dipeptidase-1, -3 and -3 in brain Mus musculus
-
skeletal muscle expression of membrane-bound dipeptidase-3 is not detectable, weak expression of membrane-bound dipeptidase-1 and membrane-bound dipeptidase-2 Mus musculus
-
spleen expression of membrane-bound dipeptidase-1 and membrane-bound dipeptidase-3 is not detectable, weak activity of membrane-bound dipeptidase-2 Mus musculus
-
testis membrane-bound dipeptidase-3 is detected only in testis, membrane-bound dipeptidase-1 and membrane-bound dipeptidase-2 is expressed at high levels Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-lactam + H2O
-
 Mus musculus ?
-
 ?
L-cystinyl-bis-Gly + H2O
-
 Mus musculus L-Cys + Gly-Gly
-
 ?
L-cystinyl-bis-glycine + H2O membrane-bound dipeptidase-2 cleaves leukotriene D4 but not cystinyl-bis-glycine while membrane-bound dipeptidase-3 cleaves cystinyl-bis-glycine but not LTD4 Mus musculus ?
-
 ?
leukotriene D4 + H2O membrane-bound dipeptidase-2 cleaves leukotriene D4 but not cystinyl-bis-glycine while membrane-bound dipeptidase-3 cleaves cystinyl-bis-glycine but not LTD4 Mus musculus ?
-
 ?