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Literature summary for 3.3.2.6 extracted from

  • Paige, M.; Wang, K.; Burdick, M.; Park, S.; Cha, J.; Jeffery, E.; Sherman, N.; Shim, Y.M.
    Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema (2014), J. Immunol., 192, 5059-5068.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.6

Inhibitors

Inhibitors Comment Organism Structure
additional information cigarette smoke exposure acidifies the airspaces and induced localization of the LTA4H protein into the nuclei of the epithelial cells. This results in accumulation of proline-glycine-proline in the airspaces by suppressing the LTA4H aminopeptidase activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O aminopeptidase activity Mus musculus L-Ala + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
-
 Mus musculus
LTA4H
-
 Mus musculus

General Information

General Information Comment Organism
malfunction cigarette smoke exposure promotes the development of cigarette smoke-induced emphysema by suppressing the enzymatic activities of the LTA4H aminopeptidase in lung tissues Mus musculus