Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine, to 1.9 A resolution, space group P212121. The inhibitor binds along the sequence signature for M1 aminopeptidases, GXMEN. It exhibits bidentate chelation of the catalytic zinc and binds to LTA4H's enzymatically essential carboxylate recognition site. The inhibitor binds in an extended beta-sheet conformation between the zinc ion and Arg563. The carboxyl moiety forms two hydrogen bonds with Arg563, and the hydroxamate moiety chelates the zinc ion in a bidentate fashion | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine | i.e. kelatorphan, potent inhibitor of Zn-metalloenzymes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09960 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
LTA4H | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00017 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N-[3(R)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl]-L-alanine |