Literature summary for 3.3.2.6 extracted from

Davies, D.R.; Mamat, B.; Magnusson, O.T.; Christensen, J.; Haraldsson, M.H.; Mishra, R.; Pease, B.; Hansen, E.; Singh, J.; Zembower, D.; Kim, H.; Kiselyov, A.S.; Burgin, A.B.; Gurney, M.E.; Stewart, L.J.
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography (2009), J. Med. Chem., 52, 4694-4715.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(4-fluorophenyl)(pyridin-4-yl)methanone	-	Homo sapiens
(R)-2-[4-(4-thiophene-3-ylbenzoyl)phenoxymethyl]pyrrolidine	-	Homo sapiens
1-(2,2'-bithiophen-5-yl)methanamine	-	Homo sapiens
1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid	-	Homo sapiens
1-[4-(thiophen-2-yl)phenyl]methanamine	-	Homo sapiens
1H-indol-5-ol	-	Homo sapiens
3-(benzyloxy)pyridin-2-amine	-	Homo sapiens
4-(2-amino-1,3-thiazol-4-yl)phenol	-	Homo sapiens
4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid	i.e. DG-051	Homo sapiens
5-(2-pyrrolidin-1-ylethoxy)-1H-indole	-	Homo sapiens
5-chloro-1H-indole	-	Homo sapiens
5-fluoro-1H-indole	-	Homo sapiens
benzyl[4-((R)-1-pyrrolidin-2-ylmethoxy)phenyl]amine	-	Homo sapiens
bestatin	-	Homo sapiens
dihydroresveratrol	-	Homo sapiens
additional information	structure-based drug discovery, inhibitor binding and molecular docking, overview	Homo sapiens
N-methyl-1-[2-(thiophen-2-yl)phenyl]methanamine	-	Homo sapiens
pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol	-	Homo sapiens
resveratrol	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
leukotriene A4 + H2O	Homo sapiens	-	leukotriene B4	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09960	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-
commercial preparation	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
leukotriene A4 + H2O	-	Homo sapiens	leukotriene B4	-	?

Synonyms

Synonyms	Comment	Organism
leukotriene A4 hydrolase	-	Homo sapiens
LTA4H	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)