Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051, a phase II clinical candidate | Canis lupus familiaris | |
4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051, a phase II clinical candidate | Homo sapiens | |
4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051, a phase II clinical candidate | Rattus norvegicus | |
4-[(2S)-2-[[4-(4-chloro-2-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051 M1-A, a derivative derived from DG-051 | Canis lupus familiaris | |
4-[(2S)-2-[[4-(4-chloro-2-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051 M1-A, a derivative derived from DG-051 | Homo sapiens | |
4-[(2S)-2-[[4-(4-chloro-2-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051 M1-A, a derivative derived from DG-051 | Rattus norvegicus | |
4-[(2S)-2-[[4-(4-chloro-3-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051 M1-B, a derivative derived from DG-051 | Canis lupus familiaris | |
4-[(2S)-2-[[4-(4-chloro-3-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051 M1-B, a derivative derived from DG-051 | Homo sapiens | |
4-[(2S)-2-[[4-(4-chloro-3-hydroxyphenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | i.e. DG-051 M1-B, a derivative derived from DG-051 | Rattus norvegicus | |
4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-oxidopyrrolidin-1-yl]butanoic acid | i.e. DG-051 M2, an N-oxide derivative derived from DG-051 | Canis lupus familiaris | |
4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-oxidopyrrolidin-1-yl]butanoic acid | i.e. DG-051 M2, an N-oxide derivative derived from DG-051 | Homo sapiens | |
4-[(2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-oxidopyrrolidin-1-yl]butanoic acid | i.e. DG-051 M2, an N-oxide derivative derived from DG-051 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Canis lupus familiaris | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | LTA4H is a zinc metalloprotease | Homo sapiens | |
Zn2+ | LTA4H is a zinc metalloprotease | Rattus norvegicus | |
Zn2+ | LTA4H is a zinc metalloprotease | Canis lupus familiaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Homo sapiens | - |
leukotriene B4 | - |
? | |
leukotriene A4 + H2O | Rattus norvegicus | - |
leukotriene B4 | - |
? | |
leukotriene A4 + H2O | Canis lupus familiaris | - |
leukotriene B4 | - |
? | |
additional information | Homo sapiens | LTA4H is a zinc metalloprotease | ? | - |
? | |
additional information | Rattus norvegicus | LTA4H is a zinc metalloprotease | ? | - |
? | |
additional information | Canis lupus familiaris | LTA4H is a zinc metalloprotease | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | - |
Rattus norvegicus | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | - |
Canis lupus familiaris | leukotriene B4 | - |
? | |
additional information | LTA4H is a zinc metalloprotease | Homo sapiens | ? | - |
? | |
additional information | LTA4H is a zinc metalloprotease | Rattus norvegicus | ? | - |
? | |
additional information | LTA4H is a zinc metalloprotease | Canis lupus familiaris | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
leukotriene A4 hydrolase | - |
Homo sapiens |
leukotriene A4 hydrolase | - |
Rattus norvegicus |
leukotriene A4 hydrolase | - |
Canis lupus familiaris |
LTA4H | - |
Homo sapiens |
LTA4H | - |
Rattus norvegicus |
LTA4H | - |
Canis lupus familiaris |
General Information | Comment | Organism |
---|---|---|
metabolism | LTA4H catalyzes the last step in the synthesis of the pro-inflammatory molecule leukotriene B4 | Homo sapiens |
metabolism | LTA4H catalyzes the last step in the synthesis of the pro-inflammatory molecule leukotriene B4 | Rattus norvegicus |
metabolism | LTA4H catalyzes the last step in the synthesis of the pro-inflammatory molecule leukotriene B4 | Canis lupus familiaris |