Literature summary for 3.3.2.6 extracted from

Grice, C.A.; Tays, K.L.; Savall, B.M.; Wei, J.; Butler, C.R.; Axe, F.U.; Bembenek, S.D.; Fourie, A.M.; Dunford, P.J.; Lundeen, K.; Coles, F.; Xue, X.; Riley, J.P.; Williams, K.N.; Karlsson, L.; Edwards, J.P.
Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity (2008), J. Med. Chem., 51, 4150-4169.

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf-9 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
(1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)methanol	-	Homo sapiens
(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)-carbamic acid tert-butyl ester	-	Homo sapiens
(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)-methanol	-	Homo sapiens
1'-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl][1,4']bipiperidinyl-2-one	-	Homo sapiens
1-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)pyrrolidin-2-one	-	Homo sapiens
1-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)pyrrolidin-2-one	-	Homo sapiens
1-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]pyrrolidin-2-one	-	Homo sapiens
1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol	-	Homo sapiens
1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol	-	Homo sapiens
1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol	-	Homo sapiens
1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol	-	Homo sapiens
1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-ylamine	-	Homo sapiens
1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidine-4-carboxylic acid amide	-	Homo sapiens
1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ol	-	Homo sapiens
1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidine-4-carboxylic acid amide	-	Homo sapiens
1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ol	-	Homo sapiens
1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid	-	Homo sapiens
1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid amide	-	Homo sapiens
2-(4-piperidin-1-ylmethylphenoxy)benzothiazole	-	Homo sapiens
2-[4-(2-azepan-1-ylethoxy)phenoxy]-1H-benzoimidazole	-	Homo sapiens
2-[4-(2-azepan-1-ylethoxy)phenoxy]benzooxazole	-	Homo sapiens
2-[4-(2-azepan-1-ylethoxy)phenoxy]benzothiazole	-	Homo sapiens
2-[4-(2-morpholin-4-ylethoxy)phenoxy]-1-(2-trimethylsilanylethoxymethyl)-1H-benzoimidazole	-	Homo sapiens
2-[4-(2-morpholin-4-ylethoxy)phenoxy]-1H-benzoimidazole	-	Homo sapiens
2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzooxazole	-	Homo sapiens
2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzothiazole	-	Homo sapiens
2-[4-(2-piperidin-1-ylethoxy)phenoxy]-1H-benzoimidazole	-	Homo sapiens
2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzooxazole	-	Homo sapiens
2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzothiazole	-	Homo sapiens
2-[4-(2-piperidin-1-ylethyl)phenoxy]benzothiazole	-	Homo sapiens
2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]-1H-benzoimidazole	-	Homo sapiens
2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzooxazole	-	Homo sapiens
2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzothiazole	-	Homo sapiens
3-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)oxazolidin-2-one	-	Homo sapiens
3-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)oxazolidin-2-one	-	Homo sapiens
3-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]oxazolidin-2-one	-	Homo sapiens
acetic acid (1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ylcarbamoyl)methyl ester	-	Homo sapiens
acetic acid [1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ylcarbamoyl]methyl ester	-	Homo sapiens
DG-051	-	Homo sapiens
N-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)acetamide	-	Homo sapiens
N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]-2-hydroxyacetamide	-	Homo sapiens
N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]acetamide	-	Homo sapiens
SC-57461A	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	contains zinc	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
leukotriene A4 + H2O	-	Homo sapiens	leukotriene B4	-	?

Synonyms

Synonyms	Comment	Organism
leukotriene A4 hydrolase	contains both hydrolase and aminopeptidase activity	Homo sapiens
LTA4H	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000004	-	-	Homo sapiens	2-[4-(2-azepan-1-ylethoxy)phenoxy]benzooxazole
0.000006	-	-	Homo sapiens	1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol
0.000007	-	-	Homo sapiens	2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzooxazole
0.000008	-	-	Homo sapiens	1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ol
0.000008	-	-	Homo sapiens	N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]-2-hydroxyacetamide
0.000009	-	-	Homo sapiens	1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol
0.00001	-	-	Homo sapiens	3-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]oxazolidin-2-one
0.000011	-	-	Homo sapiens	2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzooxazole
0.000011	-	-	Homo sapiens	3-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)oxazolidin-2-one
0.000011	-	-	Homo sapiens	1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid
0.000012	-	-	Homo sapiens	1-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]pyrrolidin-2-one
0.000012	-	-	Homo sapiens	N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]acetamide
0.000013	-	-	Homo sapiens	(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)-methanol
0.000013	-	-	Homo sapiens	1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidine-4-carboxylic acid amide
0.000013	-	-	Homo sapiens	1-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)pyrrolidin-2-one
0.000014	-	-	Homo sapiens	(1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)methanol
0.000014	-	-	Homo sapiens	2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzothiazole
0.000016	-	-	Homo sapiens	1-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)pyrrolidin-2-one
0.000017	-	-	Homo sapiens	2-[4-(2-piperidin-1-ylethyl)phenoxy]benzothiazole
0.000017	-	-	Homo sapiens	1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid amide
0.000021	-	-	Homo sapiens	acetic acid [1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ylcarbamoyl]methyl ester
0.000028	-	-	Homo sapiens	1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidine-4-carboxylic acid amide
0.000029	-	-	Homo sapiens	3-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)oxazolidin-2-one
0.000031	-	-	Homo sapiens	1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol
0.000034	-	-	Homo sapiens	1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ol
0.000035	-	-	Homo sapiens	N-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)acetamide
0.00005	-	-	Homo sapiens	acetic acid (1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ylcarbamoyl)methyl ester
0.000054	-	-	Homo sapiens	2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzothiazole
0.000058	-	-	Homo sapiens	2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzooxazole
0.000059	-	-	Homo sapiens	2-(4-piperidin-1-ylmethylphenoxy)benzothiazole
0.000066	-	-	Homo sapiens	2-[4-(2-azepan-1-ylethoxy)phenoxy]benzothiazole
0.000066	-	-	Homo sapiens	1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol
0.00007	-	-	Homo sapiens	1'-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl][1,4']bipiperidinyl-2-one
0.000084	-	-	Homo sapiens	2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]-1H-benzoimidazole
0.00011	-	-	Homo sapiens	2-[4-(2-piperidin-1-ylethoxy)phenoxy]-1H-benzoimidazole
0.00014	-	-	Homo sapiens	2-[4-(2-azepan-1-ylethoxy)phenoxy]-1H-benzoimidazole
0.00035	-	-	Homo sapiens	2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzothiazole
0.003	-	-	Homo sapiens	2-[4-(2-morpholin-4-ylethoxy)phenoxy]-1H-benzoimidazole