Literature summary for 3.3.2.6 extracted from

Albrecht, S.; Defoin, A.; Salomon, E.; Tarnus, C.; Wetterholm, A.; Haeggstroem, J.Z.
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors (2006), Bioorg. Med. Chem., 14, 7241-7257.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime	-	Homo sapiens
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime	-	Homo sapiens
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime	-	Homo sapiens
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime	-	Homo sapiens
bestatin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ala-4-nitroanilide + H2O	-	Homo sapiens	Ala + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
LTA4H	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.006	-	3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime	-	Homo sapiens
0.008	-	3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime	-	Homo sapiens
0.03	-	3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0005	-	-	Homo sapiens	bestatin
0.5	-	-	Homo sapiens	3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime

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Release 2023.1 (January 2023)