Application | Comment | Organism |
---|---|---|
medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E318A | the exposure of mutant enzyme to leukotriene A4, leukotriene methyl ester or leukotriene ethyl ester results in covalent modification of peptide K21 to the same extent as for wild-type enzyme | Homo sapiens |
Y378F | mutant is only partially protected against inactivation by leukotriene methyl ester and leukotriene ethyl ester | Homo sapiens |
Y378Q | mutant is only partially protected against inactivation by leukotriene methyl ester and leukotriene ethyl ester | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
leukotriene A4 | comparison of inactivation of wild-type and mutant enzymes; suicide inactivation | Homo sapiens | |
leukotriene A4 ethyl ester | comparison of inactivation of wild-type and mutant enzymes | Homo sapiens | |
leukotriene A4 methyl ester | comparison of inactivation of wild-type and mutant enzymes | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | zinc protein | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Homo sapiens | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Homo sapiens | leukotriene B4 | - |
? |