Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.3.2.6 extracted from

  • Haeggström, J.; Radmark, O.; Fitzpatrick, F.A.
    Leukotriene A4-hydrolase activity in guinea pig and human liver (1985), Biochim. Biophys. Acta, 835, 378-384.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Cavia porcellus
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information enzyme is susceptible to proteolytic digestion Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Cavia porcellus
-
kidney
-
Homo sapiens
-
liver
-
Cavia porcellus
-
liver
-
Homo sapiens
-
lung
-
Cavia porcellus
-
lung
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
-20°C, 95% of activity after 12 days Cavia porcellus
4°C, 50% loss of activity after 12 days Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
Cavia porcellus leukotriene B4
-
?
leukotriene A4 + H2O
-
Homo sapiens leukotriene B4
-
?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
56
-
1 h, complete loss of activity Cavia porcellus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8.5
-
Cavia porcellus