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Literature summary for 3.3.2.6 extracted from

  • Samuelsson, B.; Funk, C.D.
    Enzymes involved in the biosynthesis of leukotriene B4 (1989), J. Biol. Chem., 264, 19469-19472.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Cavia porcellus
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
leukotriene A4
-
Cavia porcellus
leukotriene A4 suicide inactivation Homo sapiens
leukotriene A4
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Cavia porcellus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
?
leukotriene A4 + H2O Rattus norvegicus biosynthesis of leukotriene B4 leukotriene B4
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
leukocyte
-
Rattus norvegicus
-
leukocyte peripheral Homo sapiens
-
liver
-
Cavia porcellus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
lung
-
Cavia porcellus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
neutrophil
-
Homo sapiens
-
neutrophil
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
Cavia porcellus leukotriene B4
-
?
leukotriene A4 + H2O
-
Homo sapiens leukotriene B4
-
?
leukotriene A4 + H2O
-
Rattus norvegicus leukotriene B4
-
?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Rattus norvegicus leukotriene B4
-
?