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Literature summary for 3.3.2.6 extracted from
- Cytosolic liver enzymes catalyzing hydrolysis of leukotriene A4 to leukotriene B4 and 5,6-dihydroxyeicosatetraenoic acid (1990), Methods Enzymol., 187, 324-334.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| leukotriene A4 | - |
Cavia porcellus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Cavia porcellus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Cavia porcellus | 5829 | - |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| additional information | without any organic solvent at pH 7.4 and 25°C the half-life is less than 10 s | Cavia porcellus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + H2O | i.e. 5(S)-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid | Cavia porcellus | leukotriene B4 | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
without any organic solvent at pH 7.4 the half-life is less than 10 s, stability increases at lower temperature | Cavia porcellus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Cavia porcellus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
without any organic solvent at 25°C the half-life is less than 10 s, stability increases at higher pH | Cavia porcellus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Cavia porcellus | chromatofocusing | - |
6.2 |
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