Activating Compound | Comment | Organism | Structure |
---|---|---|---|
complementation groups B genes | CSB stimulates incision activity of NEIL1 | Mus musculus | |
complementation groups B genes | CSB stimulates incision activity of NEIL1, and CSB stimulates the NEIL1-mediated AP lyase activity 3fold | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
nucleus | - |
Mus musculus | 5634 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence | ? | - |
? | |
additional information | Homo sapiens | NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence | Mus musculus | ? | - |
? | |
additional information | NEIL1 is active on DNA lesions in ssDNA, particularly in the context of a single-stranded bubble in a duplex sequence | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
endonuclease VIII-like DNA glycosylase | - |
Mus musculus |
endonuclease VIII-like DNA glycosylase | - |
Homo sapiens |
NEIL1 | - |
Mus musculus |
NEIL1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | csb-/- mice with Cockayne syndrome, a segmental premature aging syndrome with progressive neurological degeneration caused by mutations in CS complementation groups A, CSA, or B, CSB, genes, show increased 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine concentrations in in genomic DNA and mtDNA, and reduced repair function due to mutation of the endonuclease VIII-like DNA glycosylase NEIL1, overview | Mus musculus |
malfunction | patients with Cockayne syndrome, a segmental premature aging syndrome with progressive neurological degeneration caused by mutations in CS complementation groups A, CSA, or B, CSB, genes, show increased 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine concentrations in in genomic DNA and mtDNA, and reduced repair function due to mutation of the endonuclease VIII-like DNA glycosylase NEIL1, overview | Homo sapiens |
physiological function | NEIL1 plays a role during transcription | Mus musculus |
physiological function | NEIL1 plays a role during transcription | Homo sapiens |