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Literature summary for 3.2.2.23 extracted from

  • Chan, M.K.; Ocampo-Hafalla, M.T.; Vartanian, V.; Jaruga, P.; Kirkali, G.; Koenig, K.L.; Brown, S.; Lloyd, R.S.; Dizdaroglu, M.; Teebor, G.W.
    Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA (2009), DNA Repair, 8, 786-794.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.23

Protein Variants

Protein Variants Comment Organism
additional information the content of 2,6-diamino-4-hydroxy-5-formamidopyrimidine derived guanine is increased in some but not all tissues of Neil1-/- mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,6-diamino-4-hydroxy-5-formamidopyrimidine-DNA + H2O Mus musculus
-
 2,6-diamino-4-hydroxy-5-formamidopyrimidine + DNA
-
 ?
2,6-diamino-4-hydroxy-5-formamidopyrimidine-DNA + H2O Mus musculus C57BL/6
-
 2,6-diamino-4-hydroxy-5-formamidopyrimidine + DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57/BL6 mice
-
Mus musculus C57BL/6
-
 C57/BL6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
lung cancer cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,6-diamino-4-hydroxy-5-formamidopyrimidine-DNA + H2O
-
 Mus musculus 2,6-diamino-4-hydroxy-5-formamidopyrimidine + DNA
-
 ?
2,6-diamino-4-hydroxy-5-formamidopyrimidine-DNA + H2O
-
 Mus musculus C57BL/6 2,6-diamino-4-hydroxy-5-formamidopyrimidine + DNA
-
 ?

Synonyms

Synonyms Comment Organism
NEIL1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mice lacking both NTH1 and NEIL1 demonstrate a marked increase in pulmonary and hepatic tumorigenesis compared to mice lacking either NTH1 or NEIL1. Specifically, the lung tumors contain a point mutation in codon 12 of the K-ras oncogene which is a GGT to GAT transition, overview Mus musculus