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Literature summary for 3.2.2.23 extracted from

  • Kathe, S.D.; Barrantes-Reynolds, R.; Jaruga, P.; Newton, M.R.; Burrows, C.J.; Bandaru, V.; Dizdaroglu, M.; Bond, J.P.; Wallace, S.S.
    Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases (2009), DNA Repair, 8, 643-653.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.23

Cloned(Commentary)

Cloned (Comment) Organism
gene fpg, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis Candida albicans
gene fpg, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Fpg single-turnover kinetics, overview Candida albicans
additional information
-
 additional information Fpg single-turnover kinetics, overview Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q88AH6 gene fpg
-
Candida albicans
-
 gene fpg
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Fpg prefers thymine glycol, 5-hydroxycytosine, 5-hydroxyuracil, 5,6-dihydrothymine and 5,6-dihydrouracil, over 7,8-dihydro-8-oxoguanine, the oxidation products of 8-oxoG namely, Gh:C, Sp1:C and Sp2:C are the best substrates for the enzyme, single-stranded DNA is also a substrate, no activity with 8-oxoguanine, Fpg substrate specificity, overview Candida albicans ?
-
 ?
additional information Fpg prefers thymine glycol, 5-hydroxycytosine, 5-hydroxyuracil, 5,6-dihydrothymine and 5,6-dihydrouracil, over 7,8-dihydro-8-oxoguanine, the oxidation products of 8-oxoG namely, Gh:C, Sp1:C and Sp2:C are the best substrates for the enzyme, single-stranded DNA is also a substrate, no activity with 8-oxoguanine, Fpg substrate specificity, overview Arabidopsis thaliana ?
-
 ?

Subunits

Subunits Comment Organism
More AthFpg is missing the canonical zinc finger, three-dimensional structure and primary amino acid sequence in conserved structural motifs, overview Arabidopsis thaliana
More CalFpg is missing the canonical zinc finger, three-dimensional structure and primary amino acid sequence in conserved structural motifs, overview Candida albicans

Synonyms

Synonyms Comment Organism
formamidopyrimidine DNA glycosylase
-
 Candida albicans
formamidopyrimidine DNA glycosylase
-
 Arabidopsis thaliana
FPG
-
 Candida albicans
FPG
-
 Arabidopsis thaliana
More Fpg is one of several DNA glycosylases in Arabidopsis thaliana Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Candida albicans
22
-
 assay at room temperature Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Candida albicans
7
-
 assay at Arabidopsis thaliana