Inhibitors | Comment | Organism | Structure |
---|---|---|---|
d(pA)10-d(pT)10 | dublex, nonspecific oligonucleotide | Escherichia coli | |
d(pA)16-d(pT)16 | dublex, nonspecific oligonucleotide | Escherichia coli | |
nonspecific ds 8-23mer oligonucleotide | competitive inhibitors | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
DNA containing 7-hydro-8-oxoguanine residues | pH 7.5, 25°C | Escherichia coli | |
0.0046 | - |
DNA | pH 7.5, 25°C, DNA containing an apurinic/apyrimidinic site | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + H2O | Escherichia coli | removes oxidized purines from oxidatively damaged DNA | ? | - |
? | |
DNA + H2O | Escherichia coli | DNA base excision repair enzyme | ? | - |
? | |
DNA containing 7-hydro-8-oxoguanine + H2O | Escherichia coli | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | 7-hydro-8-oxoguanine + DNA | - |
? | |
DNA containing 7-hydro-8-oxoguanine + H2O | Escherichia coli | dublex, primary physiological substrate, DNA repair | 7-hydro-8-oxoguanine + DNA | - |
? | |
DNA containing ring-opened N7-methylguanine + H2O | Escherichia coli | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine + DNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine | kinetic mechanism | Escherichia coli | |
DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine | catalytic mechanism | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + H2O | with apurinic/apyrimidinic lyase activity, catalyzes beta and delta elimination reactions | Escherichia coli | ? | - |
? | |
DNA + H2O | removes oxidized purines from oxidatively damaged DNA | Escherichia coli | ? | - |
? | |
DNA + H2O | enzyme has N-glycosylase and apurinic/apyrimidinic lyase activity | Escherichia coli | ? | - |
? | |
DNA + H2O | DNA base excision repair enzyme | Escherichia coli | ? | - |
? | |
DNA containing 7-hydro-8-oxoguanine + H2O | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | Escherichia coli | 7-hydro-8-oxoguanine + DNA | - |
? | |
DNA containing 7-hydro-8-oxoguanine + H2O | dublex, primary physiological substrate, DNA repair | Escherichia coli | 7-hydro-8-oxoguanine + DNA | - |
? | |
DNA containing 7-hydro-8-oxoguanine residues + H2O | kinetic mechanism, 3 activities: DNA-glycosylase, beta-elimination/AP-lyase and delta elimination, 12-nucleotide dublex containing 8-oxo-G in the sixth position of one strand, conformational transitions of Fpg protein during the catalytic process | Escherichia coli | DNA + 7-hydro-8-oxoguanine | - |
? | |
DNA containing ring-opened N7-methylguanine + H2O | repairs oxidative DNA damage by efficiently removing formamidopyrimidine lesions and 8-oxoguanine residues from DNA | Escherichia coli | 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine + DNA | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Escherichia coli |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
DNA containing 7-hydro-8-oxoguanine residues | pH 7.5, 25°C | Escherichia coli | |
0.05 | - |
DNA | pH 7.5, 25°C, DNA containing an apurininc/apyrimidinic site | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | with increase in dublex length of nonspecific ds 8-23mer oligonucleotides, Ki values decrease from 0.05 mM to 0.0007 mM | Escherichia coli | |
0.001 | - |
d(pA)16-d(pT)16 | pH 7.5, 25°C | Escherichia coli | |
0.0067 | - |
d(pA)10-d(pT)10 | pH 7.5, 25°C | Escherichia coli |