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Literature summary for 3.2.1.62 extracted from

  • Naim, H.Y.; Lentze, M.J.
    Impact of O-glycosylation on the function of human intestinal lactase-phlorizin hydrolase. Characterization of glycoforms varying in enzyme activity and localization of O-glycoside addition (1992), J. Biol. Chem., 267, 25494-25504.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
14
-
 4-O-beta-D-galactopyranosyl-D-glucopyranoside both mannose-rich precursor form and mature form Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
 cleaved mature form, SDS-PAGE Homo sapiens
215000
-
 mannose-rich precursor form, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O Homo sapiens 4fold higher activity for the N- and O-glycosylated than for the N-glycosylated molecule D-galactose + beta-D-glucose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein mature LPH O- and N-glycosylated, no sialic acids Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
Helix pomatia lectin chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O 4fold higher activity for the N- and O-glycosylated than for the N-glycosylated molecule Homo sapiens D-galactose + beta-D-glucose
-
 ?

Synonyms

Synonyms Comment Organism
LPH
-
 Homo sapiens