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Literature summary for 3.2.1.52 extracted from
- Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain (2001), J. Biol. Chem., 276, 9838-9845.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-acetyl-beta-D-glucosamine | inhibited by GlcNAc, but not by GalNAc | Bos taurus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | mostly localized | Bos taurus | 5829 | - |
| nucleus | - |
Bos taurus | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 103000 | - |
SDS-PAGE | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q0V8R6 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.84 | - |
purified protein | Bos taurus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| enzyme can be stored at -20°C | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O | - |
Bos taurus | 4-nitrophenol + N-acetyl-beta-D-glucosamine | - |
? | |
| additional information | p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc are no substrates. The cloned enzyme cleaves GlcNAc, but not GalNAc, from glycopeptides | Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-N-acetylglucosaminidase | - |
Bos taurus |
| neutral hexosaminidase C | - |
Bos taurus |
| O-GlcNAcase | - |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7 | - |
Bos taurus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Bos taurus | - |
- |
4.63 |
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Release 2023.1 (January 2023)
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