Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-ethylmaleimide | N-acetylgalactosaminidase | Rattus norvegicus | |
N-ethylmaleimide | N-acetylgalactosaminidase | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetate | inhibits N-acetylhexosaminidase | Bos taurus | |
acetate | inhibits N-acetylhexosaminidase | Rattus norvegicus | |
Ag+ | inhibits N-acetylhexosaminidase, -galactosaminidase and -glucosaminidase | Bos taurus | |
Ag+ | inhibits N-acetylhexosaminidase, -galactosaminidase and -glucosaminidase | Rattus norvegicus | |
galactosamine | inhibits N-acetylhexosaminidase | Bos taurus | |
galactosamine | inhibits N-acetylhexosaminidase | Rattus norvegicus | |
glucosamine | inhibits N-acetylhexosaminidase | Bos taurus | |
glucosamine | inhibits N-acetylhexosaminidase | Rattus norvegicus | |
N-acetyl-D-galactosamine | inhibits N-acetylhexosaminidase and -galactosaminidase | Bos taurus | |
N-acetyl-D-galactosamine | inhibits N-acetylhexosaminidase and -galactosaminidase | Rattus norvegicus | |
N-acetyl-D-glucosamine | inhibits N-acetylhexosaminidase and -glucosaminidase | Bos taurus | |
N-acetyl-D-glucosamine | inhibits N-acetylhexosaminidase and -glucosaminidase | Rattus norvegicus | |
N-ethylmaleimide | N-acetylglucosaminidase | Bos taurus | |
N-ethylmaleimide | N-acetylglucosaminidase | Rattus norvegicus | |
p-hydroxymercuribenzoate | inhibits N-acetylhexosaminidase, -galactosaminidase and -glucosaminidase | Bos taurus | |
p-hydroxymercuribenzoate | inhibits N-acetylhexosaminidase, -galactosaminidase and -glucosaminidase | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.35 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | N-acetylgalactosaminidase | Rattus norvegicus | |
0.35 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | N-acetylgalactosaminidase | Bos taurus | |
0.54 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | N-acetylhexosaminidase | Rattus norvegicus | |
0.54 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | N-acetylhexosaminidase | Bos taurus | |
0.72 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | N-acetylglucosaminidase | Rattus norvegicus | |
0.72 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | N-acetylglucosaminidase | Bos taurus | |
0.8 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | N-acetylhexosaminidase | Rattus norvegicus | |
0.8 | - |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | N-acetylhexosaminidase | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-beta-D-hexosaminides + H2O | Rattus norvegicus | - |
N-acetyl-D-hexosamines | - |
? | |
N-acetyl-beta-D-hexosaminides + H2O | Bos taurus | - |
N-acetyl-D-hexosamines | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calf | - |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
N-acetylglucosaminidase and -galactosaminidase | Rattus norvegicus |
N-acetylhexosaminidase: 63fold | Rattus norvegicus |
N-acetylhexosaminidase: 63fold, N-acetylglucosaminidase and -galactosaminidase | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.03 | - |
N-acetylhexosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | Rattus norvegicus |
0.03 | - |
N-acetylhexosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | Bos taurus |
0.22 | - |
N-acetylhexosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | Rattus norvegicus |
0.22 | - |
N-acetylhexosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | Bos taurus |
Storage Stability | Organism |
---|---|
-20°C, N-acetyl-glucosaminidase and -galactosaminidase completely lose activity after several days | Rattus norvegicus |
-20°C, N-acetyl-glucosaminidase and -galactosaminidase completely lose activity after several days | Bos taurus |
-20°C, N-acetyl-hexosaminidase, in presence of ammonium sulfate, after several weeks: precipitate devoid of enzymatic activity forms but can be removed by centrifugation, further purification: loss of activity after several days at -20°C | Rattus norvegicus |
-20°C, N-acetyl-hexosaminidase, in presence of ammonium sulfate, after several weeks: precipitate devoid of enzymatic activity forms but can be removed by centrifugation, further purification: loss of activity after several days at -20°C | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chitobiose + H2O | - |
Rattus norvegicus | 2 D-glucosamine | - |
? | |
chitobiose + H2O | - |
Bos taurus | 2 D-glucosamine | - |
? | |
lacto-N-triose + H2O | - |
Rattus norvegicus | ? | - |
? | |
lacto-N-triose + H2O | - |
Bos taurus | ? | - |
? | |
N-acetyl-beta-D-glucosaminide-1,4-muramic acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
N-acetyl-beta-D-glucosaminide-1,4-muramic acid + H2O | - |
Bos taurus | ? | - |
? | |
N-acetyl-beta-D-hexosaminides + H2O | - |
Rattus norvegicus | N-acetyl-D-hexosamines | - |
? | |
N-acetyl-beta-D-hexosaminides + H2O | - |
Bos taurus | N-acetyl-D-hexosamines | - |
? | |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside + H2O | - |
Rattus norvegicus | 2-acetamido-2-deoxy-D-galactose + p-nitrophenol | - |
? | |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside + H2O | - |
Bos taurus | 2-acetamido-2-deoxy-D-galactose + p-nitrophenol | - |
? | |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside + H2O | - |
Rattus norvegicus | 2-acetamido-2-deoxy-D-glucose + p-nitrophenol | - |
? | |
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside + H2O | - |
Bos taurus | 2-acetamido-2-deoxy-D-glucose + p-nitrophenol | - |
? | |
phenyl-N-acetyl-beta-D-glucosaminide + H2O | - |
Rattus norvegicus | phenol + N-acetyl-beta-D-glucosaminide | - |
? | |
phenyl-N-acetyl-beta-D-glucosaminide + H2O | - |
Bos taurus | phenol + N-acetyl-beta-D-glucosaminide | - |
? | |
trihexosylceramide + H2O | - |
Rattus norvegicus | ? | - |
? | |
trihexosylceramide + H2O | - |
Bos taurus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3.8 | - |
substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside, N-acetylhexosaminidase | Rattus norvegicus |
3.8 | - |
substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside, N-acetylhexosaminidase | Bos taurus |
4.2 | - |
substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside, N-acetylhexosaminidase | Rattus norvegicus |
4.2 | - |
substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside, N-acetylhexosaminidase | Bos taurus |
5.2 | - |
N-acetylglucosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | Rattus norvegicus |
5.2 | - |
N-acetylglucosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside | Bos taurus |
5.5 | - |
N-acetylgalactosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | Rattus norvegicus |
5.5 | - |
N-acetylgalactosaminidase, substrate: p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside | Bos taurus |