Crystallization (Comment) | Organism |
---|---|
in complex beta-cyclodextrin and either 5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin or 5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thionojirimycin, microbatch under oil method, using 0.2 M (NH4)2SO4, 0.1 M Tris pH 6.5, and 25% (w/v) PEG3350 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin | potent inhibitor | Homo sapiens | |
5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thionojirimycin | potent inhibitor | Homo sapiens | |
6-amino-6-deoxy-5-N,6-N-[N'-(n-octyl)iminomethylidene]nojirimycin | - |
Homo sapiens | |
additional information | isofagomine is not specific for the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucosylceramide + H2O | - |
Homo sapiens | beta-D-glucose + ceramide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid beta-glucosidase | - |
Homo sapiens |
beta-glucocerebrosidase | - |
Homo sapiens |
GlcCerase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations in the gene encoding for acid beta-glucosidase result in Gaucher disease | Homo sapiens |