Literature summary for 3.2.1.45 extracted from

Alessandrini, F.; Pfister, S.; Kremmer, E.; Gerber, J.K.; Ring, J.; Behrendt, H.
Alterations of glycosylceramide-beta-glucosidase levels in the skin of patients with Psoriasis vulgaris (2004), J. Invest. Dermatol., 123, 1030-1036.

Search for more literature for 3.2.1.45

Application

Application	Comment	Organism
medicine	enzyme activity is decreased in psoriatic skin compared to normal control, increased in lesional compared to non-lesional psoriatic skin. Alterations in water permeability barrier in lesional psoriatic skin can serve as a trigger for the upregulation of the expression of enzymes like glycosylceramide-beta-glucosidase with consequent stimulation of ceramide generation	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with Psoriasis vulgaris	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	mainly present in the upper epidermis, decreased in psoriatic skin compared to normal control, increased in lesional compared to non-lesional psoriatic skin	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Glc-Cerase	-	Homo sapiens
glycosylceramide-beta-glucosidase	-	Homo sapiens

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Release 2023.1 (January 2023)