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Literature summary for 3.2.1.45 extracted from

  • Kim, E.Y.; Hong, Y.B.; Lai, Z.; Kim, H.J.; CHO, Y.H.; Brady, R.O.; Jung, S.C.
    Expression and secretion of human glucocerebrosidase mediated by recombinant lentivirus vectors in vitro and in vivo: implications for gene therapy of gaucher disease (2004), Biochem. Biophys. Res. Commun., 318, 381-390.
    View publication on PubMed

Application

Application Comment Organism
medicine lentivirus-mediated gene transfer results in high-level glucocerebrosidase expression in multiple tissues without any evidence of local or systemic toxicity. Lentivirus-mediated gene transfer may respresent an effective method of achieving widespread and persistent therapeutic benefit for the treatment of patients with Gaucher disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with Gaucher disease
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-