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Literature summary for 3.2.1.45 extracted from

  • Holleran, W.M.; Takagi, Y.; Imokawa, G.; Jackson, S.; Lee, J.M.; Elias, P.M.
    beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation (1992), J. Lipid Res., 33, 1201-1209.
    View publication on PubMed
Search for more literature for 3.2.1.45

Activating Compound

Activating Compound Comment Organism Structure
sodium taurocholate activation is pH-dependent Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
6-bromo-6-deoxy-conduritol
-
 Mus musculus
6-bromo-conduritol-beta-epoxide
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.93
-
 4-methylumbelliferyl-beta-D-glucopyranoside
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucocerebroside + H2O Mus musculus
-
 glucose + ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
epidermis highest activity in stratum corneum Mus musculus
-
liver
-
 Mus musculus
-
spleen
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Mus musculus methylumbelliferone + glucose
-
 ?
glucocerebroside + H2O
-
 Mus musculus glucose + ceramide
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6
-
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
4.8 5.8
-
 Mus musculus