Literature summary for 3.2.1.45 extracted from

Schram, A.W.; Aerts, J.M.F.G.; van Weely, S.; Barranger, J.A.; Tager, J.M.
Glucocerebrosidase, a membrane-associated lysosomal enzyme deficient in Gaucher disease (1987), Methodol. Surv. Biochem. Anal., 17, 113-126.

No PubMed abstract available

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Inhibitors

Inhibitors	Comment	Organism	Structure
(1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-
membrane	-	Homo sapiens	16020	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
59000	-	gel filtration, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glucocerebroside + H2O	Homo sapiens	-	glucose + ceramide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	contains mannose residues	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Homo sapiens	-
urine	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl-beta-D-glucopyranoside + H2O	-	Homo sapiens	methylumbelliferone + glucose	-	?
glucocerebroside + H2O	-	Homo sapiens	glucose + ceramide	-	?

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Release 2023.1 (January 2023)