Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.45 extracted from

  • Osiecki-Newman, K.; Fabbro, D.; Legler, G.; Desnick, R.J.; Grabowski, G.A.
    Human acid beta-glucosidase: use of inhibitors, alternative substrates and amphiphiles to investigate the properties of the normal and Gaucher disease active sites (1987), Biochim. Biophys. Acta, 915, 87-100.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-deoxynojirimycin
-
Homo sapiens
alkyl amines
-
Homo sapiens
Alkyl beta-glucosides
-
Homo sapiens
N-butyl-1-deoxynojirimycin
-
Homo sapiens
N-decyl-1-deoxynojirimycin
-
Homo sapiens
N-dodecyl-1-deoxynojirimycin
-
Homo sapiens
N-methyl-1-deoxynojirimycin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
D-glucosyl-N-methylsphingosine
-
Homo sapiens
0.02
-
D-glucosyl-N-propylsphingosine
-
Homo sapiens
0.028
-
stearylglucosyl ceramide
-
Homo sapiens
0.03
-
6(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexanoyl-2-N-sphingosyl 1-O-beta-D-glucoside
-
Homo sapiens
0.032
-
D-glucosyl-N-ethylsphingosine
-
Homo sapiens
0.033
-
D-glucosyl-N-octylsphingosine
-
Homo sapiens
0.034
-
palmitylglucosyl ceramide
-
Homo sapiens
0.042
-
D-glucosyl-N-butylsphingosine
-
Homo sapiens
0.05
-
12(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexyl-2-N-sphingosyl 1-O-beta-D-glucoside
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucocerebroside + H2O Homo sapiens
-
glucose + ceramide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
normal and Gaucher disease enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-
spleen
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminododecanoyl-2-N-sphingosyl 1-O-beta-D-glucoside + H2O
-
Homo sapiens D-glucose + 12(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminododecanoyl-2-N-sphingosine
-
?
6(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexyl-2-N-sphingosyl 1-O-beta-D-glucoside + H2O NBD-glucocerebroside Homo sapiens D-glucose + 6(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminohexyl-2-N-sphingosine
-
?
D-glucosyl-N-butylsphingosine + H2O
-
Homo sapiens D-glucose + N-butylsphingosine
-
?
D-glucosyl-N-ethylsphingosine + H2O
-
Homo sapiens D-glucose + N-ethylsphingosine
-
?
D-glucosyl-N-methylsphingosine + H2O
-
Homo sapiens D-glucose + N-methylsphingosine
-
?
D-glucosyl-N-octylsphingosine + H2O
-
Homo sapiens D-glucose + N-octylsphingosine
-
?
D-glucosyl-N-propylsphingosine + H2O
-
Homo sapiens D-glucose + N-propylsphingosine
-
?
glucocerebroside + H2O
-
Homo sapiens glucose + ceramide
-
?
N-stearoylglucosyl ceramide + H2O
-
Homo sapiens D-glucose + stearoylceramide
-
?
palmitylglucosyl ceramide + H2O
-
Homo sapiens D-glucose + palmitylceramide
-
?
stearylglucosyl ceramide + H2O
-
Homo sapiens D-glucose + stearylceramide
-
?