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Literature summary for 3.2.1.45 extracted from
- Characterization of the phospholipid requirement of a rat liver beta-glucosidase (1984), Biochem. J., 224, 515-524.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heat-stable factor | - |
Rattus norvegicus | |
| phosphatidylglycerol | acidic phospholipids, fatty acid composition important, higher activation in combination with heat-stable factor | Rattus norvegicus |  |
| phosphatidylserine | - |
Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glucosylsphingosine | - |
Rattus norvegicus | |
| N-hexyl-D-glucosylsphingosine | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.7 | - |
4-methylumbelliferyl-beta-D-glucopyranoside | in presence of phosphatidylserine and heat-stable factor | Rattus norvegicus | |
| 24 | - |
4-methylumbelliferyl-beta-D-glucopyranoside | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Rattus norvegicus | 5764 | - |
| membrane | bound | Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucocerebroside + H2O | Rattus norvegicus | - |
glucose + ceramide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-beta-D-glucopyranoside + H2O | - |
Rattus norvegicus | methylumbelliferone + glucose | - |
? | |
| glucocerebroside + H2O | - |
Rattus norvegicus | glucose + ceramide | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
for 0-30 min, maximum protection with heat-stable factor | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 5 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 6 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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