Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin 1-beta | acts synergistically with TNF-alpha to increase gene expression and activity | Homo sapiens | |
TNF-alpha | acts synergistically with interleukin 1-beta to increase gene expression and activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in human bronchial epithelial cell (HBE) | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
intracellular | - |
Homo sapiens | 5622 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | also expressed at the apical pole associated with the plasma membrane in bronchial epithelial cells | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | ? | - |
? | |
additional information | Homo sapiens | Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | ? | - |
? | |
additional information | Homo sapiens | Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43820 | - |
- |
Homo sapiens | O43820 | expression in human bronchial epithelial cell (HBE) | - |
Homo sapiens | Q12794 | - |
- |
Homo sapiens | Q12794 | expression in human bronchial epithelial cell (HBE) | - |
Homo sapiens | Q12891 | - |
- |
Homo sapiens | Q12891 | expression in human bronchial epithelial cell (HBE) | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchial epithelial cell | Hyal-like activity is present in the apical and basolateral secretions from HBE cells where Hyals 1, 2, and 3 are expressed | Homo sapiens | - |
bronchoalveolar lavage | increased expression and activity is observed in tracheal sections and in bronchoalveolar lavage (BAL) obtained from subjects with asthma when compared with normal lung donors and healthy volunteers | Homo sapiens | - |
tracheobronchial epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | Homo sapiens | ? | - |
? | |
additional information | Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | Homo sapiens | ? | - |
? | |
additional information | Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hyal 1 | - |
Homo sapiens |
HYAL1 | - |
Homo sapiens |
Hyal2 | - |
Homo sapiens |
HYAL3 | - |
Homo sapiens |
hyaluronidase | - |
Homo sapiens |
hyaluronidase 2 | - |
Homo sapiens |
hyaluronidase 3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.2 | - |
assay at | Homo sapiens |