Literature summary for 3.2.1.33 extracted from

Nelson, T.E.; Larner, J.
Studies on the action of amylo-I,6-glucosidase (1970), Biochim. Biophys. Acta, 198, 538-545.

Search for more literature for 3.2.1.33

Inhibitors

Inhibitors	Comment	Organism	Structure
Tris	-	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
6-O-alpha-D-glucosyl cyclomaltoheptaose + H2O = D-glucose + cyclomaltoheptaose	mechanism	Oryctolagus cuniculus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	-	Oryctolagus cuniculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
7.7	-	-	Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 D-glucose	-	Oryctolagus cuniculus	6-O-alpha-D-glucosyl-D-glucose + H2O	isomaltose	r
63-alpha-glucosyl maltotetraose + H2O	branched pentasaccharide "fast B5"	Oryctolagus cuniculus	maltotetraose + D-glucose	-	r
alpha-(1-6)-glucosyl cyclohexaamylose + H2O	6-alpha-glucosyl alpha-Schardinger dextrin, cyclodextrin	Oryctolagus cuniculus	cyclohexaamylose + D-glucose	-	r
glycogen + H2O	reverse reaction: incorporation of glucose into glycogen	Oryctolagus cuniculus	glycogen + D-glucose	-	r
glycogen phosphorylase-limit dextrin + H2O	-	Oryctolagus cuniculus	limit dextrin + D-glucose	-	r

Synonyms

Synonyms	Comment	Organism
glycogen debranching system	EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system	Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
additional information	-	pH optimum is the same in both degradative and synthetic directions and optimum is shifted and inhibited by Tris in the same manner in both directions	Oryctolagus cuniculus

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Release 2023.1 (January 2023)