Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | glycosylated at Asn173 and Asn420 with high mannose-type oligosaccharides | Homo sapiens |
phosphoprotein | both the placental 80000 Da and 64000 Da peptides, though not the 18000 Da one, are apparently phosphorylated, whereas the enzyme of leukemic cells is poorly phosphorylated | Homo sapiens |
proteolytic modification | the 80000 Da form is a protein from which a 22000 amino-acid-N-terminal signal peptide has been removed. A second cleavage occurs between the 159th and 160th amino acid to produce the 64000 Da and 18000 Da polypeptides. Thus the 18000 Da polypeptide of 137 amino acids represents the N-terminal part of the 80000 Da precursor | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | chronic myelogenous | Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme is composed of three components of 18000, 64000 and 80000 Da | Homo sapiens |