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Literature summary for 3.2.1.18 extracted from

  • Nishikawa, T.; Shimizu, K.; Tanaka, T.; Kuroda, K.; Takayama, T.; Yamamoto, T.; Hanada, N.; Hamada, Y.
    Bacterial neuraminidase rescues influenza virus replication from inhibition by a neuraminidase inhibitor (2012), PLoS ONE, 7, e45371.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.18

Application

Application Comment Organism
medicine bacterial neuraminidases functions as the predominant neuraminidase when influenza virus neuraminidase is inhibited to promote the spread of infection and to inactivate the neutralization activity of saliva. Neuraminidase from bacterial flora in patients may reduce the efficacy of neuraminidase inhibitor drugs during influenza virus infection Streptococcus pneumoniae
medicine bacterial neuraminidases functions as the predominant neuraminidase when influenza virus neuraminidase is inhibited to promote the spread of infection and to inactivate the neutralization activity of saliva. Neuraminidase from bacterial flora in patients may reduce the efficacy of neuraminidase inhibitor drugs during influenza virus infection Paenarthrobacter ureafaciens
medicine bacterial neuraminidases functions as the predominant neuraminidase when influenza virus neuraminidase is inhibited to promote the spread of infection and to inactivate the neutralization activity of saliva. Neuraminidase from bacterial flora in patients may reduce the efficacy of neuraminidase inhibitor drugs during influenza virus infection Vibrio cholerae serotype O1
medicine bacterial neuraminidases functions as the predominant neuraminidase when influenza virus neuraminidase is inhibited to promote the spread of infection and to inactivate the neutralization activity of saliva. Neuraminidase from bacterial flora in patients may reduce the efficacy of neuraminidase inhibitor drugs during influenza virus infection influenza A virus

Inhibitors

Inhibitors Comment Organism Structure
2-deoxy-2,3-dehydro-N-acetylneuraminic acid inhibition occurs in the micromolar range influenza A virus
2-deoxy-2,3-dehydro-N-acetylneuraminic acid inhibition occurs in the micromolar range Paenarthrobacter ureafaciens
2-deoxy-2,3-dehydro-N-acetylneuraminic acid inhibition occurs in the micromolar range Streptococcus pneumoniae
2-deoxy-2,3-dehydro-N-acetylneuraminic acid inhibition occurs in the micromolar range Vibrio cholerae serotype O1
zanamivir inhibition occurs in the nanomolar range influenza A virus
zanamivir inhibition occurs in the millimolar range Paenarthrobacter ureafaciens
zanamivir inhibition occurs in the millimolar range Streptococcus pneumoniae
zanamivir inhibition occurs in the millimolar range Vibrio cholerae serotype O1

Organism

Organism UniProt Comment Textmining
influenza A virus
-
-
-
Paenarthrobacter ureafaciens
-
-
-
Streptococcus pneumoniae
-
-
-
Streptococcus pneumoniae IID553
-
-
-
Vibrio cholerae serotype O1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-chloro-5-(4-methoxyspiro(1,2-dioxetane-3,29-(5-chloro)tricyclo[3.3.1.13,7]decan)-4-yl-phenyl-5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranoside)onate + H2O
-
 Streptococcus pneumoniae ?
-
 ?
2-chloro-5-(4-methoxyspiro(1,2-dioxetane-3,29-(5-chloro)tricyclo[3.3.1.13,7]decan)-4-yl-phenyl-5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranoside)onate + H2O
-
 Paenarthrobacter ureafaciens ?
-
 ?
2-chloro-5-(4-methoxyspiro(1,2-dioxetane-3,29-(5-chloro)tricyclo[3.3.1.13,7]decan)-4-yl-phenyl-5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranoside)onate + H2O
-
 Vibrio cholerae serotype O1 ?
-
 ?
2-chloro-5-(4-methoxyspiro(1,2-dioxetane-3,29-(5-chloro)tricyclo[3.3.1.13,7]decan)-4-yl-phenyl-5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranoside)onate + H2O
-
 influenza A virus ?
-
 ?
2-chloro-5-(4-methoxyspiro(1,2-dioxetane-3,29-(5-chloro)tricyclo[3.3.1.13,7]decan)-4-yl-phenyl-5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranoside)onate + H2O
-
 Streptococcus pneumoniae IID553 ?
-
 ?

Synonyms

Synonyms Comment Organism
neuraminidase
-
 Streptococcus pneumoniae
neuraminidase
-
 Paenarthrobacter ureafaciens
neuraminidase
-
 Vibrio cholerae serotype O1
neuraminidase
-
 influenza A virus