Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.18 extracted from

  • Fujisaki, S.; Imai, M.; Takashita, E.; Taniwaki, T.; Xu, H.; Kishida, N.; Yokoyama, M.; Sato, H.; Tashiro, M.; Odagiri, T.
    Mutations at the monomer-monomer interface away from the active site of influenza B virus neuraminidase reduces susceptibility to neuraminidase inhibitor drugs (2013), J. Infect. Chemother., 19, 891-895.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G140R the mutation is associated with reduced susceptibility to neuraminidase inhibitors influenza B virus
P139S the mutation is associated with reduced susceptibility to neuraminidase inhibitors influenza B virus
Q138R the mutation is associated with reduced susceptibility to neuraminidase inhibitors influenza B virus

Inhibitors

Inhibitors Comment Organism Structure
laninamivir
-
influenza B virus
oseltamivir carboxylate
-
influenza B virus
peramivir
-
influenza B virus
zanamivir
-
influenza B virus

Organism

Organism UniProt Comment Textmining
influenza B virus
-
-
-
influenza B virus B/Kochi/41/2011
-
-
-
influenza B virus B/Kochi/59/2011
-
-
-
influenza B virus B/Kochi/60/2011
-
-
-

Synonyms

Synonyms Comment Organism
neuraminidase
-
influenza B virus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000076
-
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus peramivir
0.00000079
-
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus peramivir
0.00000097
-
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus peramivir
0.0000013
-
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus zanamivir
0.00000156
-
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus zanamivir
0.00000175
-
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus zanamivir
0.00000228
-
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus oseltamivir carboxylate
0.0000026
-
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus oseltamivir carboxylate
0.00000311
-
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus laninamivir
0.0000039
-
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus oseltamivir carboxylate
0.00000419
-
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus laninamivir
0.00000468
-
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus laninamivir
0.00000498
-
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus oseltamivir carboxylate
0.00001161
-
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus laninamivir
0.0000122
-
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus zanamivir
0.00001343
-
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus laninamivir
0.00001614
-
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication influenza B virus peramivir
0.00001747
-
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus laninamivir
0.00001998
-
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus zanamivir
0.00002305
-
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus oseltamivir carboxylate
0.00002371
-
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus zanamivir
0.00002525
-
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus oseltamivir carboxylate
0.000127
-
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication influenza B virus peramivir
0.0001273
-
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication influenza B virus peramivir