Protein Variants | Comment | Organism |
---|---|---|
G140R | the mutation is associated with reduced susceptibility to neuraminidase inhibitors | influenza B virus |
P139S | the mutation is associated with reduced susceptibility to neuraminidase inhibitors | influenza B virus |
Q138R | the mutation is associated with reduced susceptibility to neuraminidase inhibitors | influenza B virus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
laninamivir | - |
influenza B virus | |
oseltamivir carboxylate | - |
influenza B virus | |
peramivir | - |
influenza B virus | |
zanamivir | - |
influenza B virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
influenza B virus | - |
- |
- |
influenza B virus B/Kochi/41/2011 | - |
- |
- |
influenza B virus B/Kochi/59/2011 | - |
- |
- |
influenza B virus B/Kochi/60/2011 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
neuraminidase | - |
influenza B virus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000076 | - |
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | peramivir | |
0.00000079 | - |
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | peramivir | |
0.00000097 | - |
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | peramivir | |
0.0000013 | - |
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | zanamivir | |
0.00000156 | - |
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | zanamivir | |
0.00000175 | - |
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | zanamivir | |
0.00000228 | - |
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | oseltamivir carboxylate | |
0.0000026 | - |
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | oseltamivir carboxylate | |
0.00000311 | - |
wild type enzyme, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | laninamivir | |
0.0000039 | - |
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | oseltamivir carboxylate | |
0.00000419 | - |
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | laninamivir | |
0.00000468 | - |
wild type enzyme, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | laninamivir | |
0.00000498 | - |
wild type enzyme, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | oseltamivir carboxylate | |
0.00001161 | - |
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | laninamivir | |
0.0000122 | - |
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | zanamivir | |
0.00001343 | - |
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | laninamivir | |
0.00001614 | - |
mutant enzyme Q138R, strain B/Kochi/60/2011, pH and temperature not specified in the publication | influenza B virus | peramivir | |
0.00001747 | - |
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | laninamivir | |
0.00001998 | - |
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | zanamivir | |
0.00002305 | - |
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | oseltamivir carboxylate | |
0.00002371 | - |
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | zanamivir | |
0.00002525 | - |
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | oseltamivir carboxylate | |
0.000127 | - |
mutant enzyme P139S, strain B/Kochi/41/2011, pH and temperature not specified in the publication | influenza B virus | peramivir | |
0.0001273 | - |
mutant enzyme G140R, strain B/Kochi/59/2011, pH and temperature not specified in the publication | influenza B virus | peramivir |