Literature summary for 3.2.1.18 extracted from

Cross, A.S.; Hyun, S.W.; Miranda-Ribera, A.; Feng, C.; Liu, A.; Nguyen, C.; Zhang, L.; Luzina, I.G.; Atamas, S.P.; Twaddell, W.S.; Guang, W.; Lillehoj, E.P.; Puche, A.C.; Huang, W.; Wang, L.X.; Passaniti, A.; Goldblum, S.E.
NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not (2012), J. Biol. Chem., 287, 15966-15980.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-dehydro-2-deoxy-N-acetylneuraminic acid	competitive inhibitor; competitive inhibitor	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
nucleus	-	Homo sapiens	5634	-
perinuclear region	-	Homo sapiens	-	-
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99519	-	-
Homo sapiens	Q9UQ49	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HMEC-1 cell	-	Homo sapiens	-
HMVEC cell	-	Homo sapiens	-
HPAEC cell	-	Homo sapiens	-
lung microvascular endothelial cell	-	Homo sapiens	-
pulmonary artery endothelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O	-	Homo sapiens	4-methylumbelliferone + N-acetylneuraminic acid	-	?

Synonyms

Synonyms	Comment	Organism
NEU1	isoform	Homo sapiens
Neu3	isoform	Homo sapiens
sialidase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	isoform NEU1 restrains the endothelial migratory response to wounding	Homo sapiens

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Release 2023.1 (January 2023)