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Literature summary for 3.2.1.18 extracted from

  • Bigi, A.; Tringali, C.; Forcella, M.; Mozzi, A.; Venerando, B.; Monti, E.; Fusi, P.
    A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation (2013), Glycobiology, 23, 1499-1509.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in SK-N-BE neuroblastoma cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane outer mitochondrial membrane Homo sapiens 31966
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
NEU4L
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Homo sapiens
sialidase
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Homo sapiens

General Information

General Information Comment Organism
metabolism NEU4 long is a downstream component of the PI3K/Akt signaling pathway required for retinoic acid-induced differentiation of neuroblastoma SK-N-BE cells Homo sapiens
physiological function the proline-rich region of NEU4 long can enhance cell proliferation and retinoic acid-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt, as well as in substrate recognition, modifying directly or through the interaction with other protein(s) the enzyme specificity toward sialylated glycoprotein(s) Homo sapiens