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Literature summary for 3.2.1.18 extracted from

  • Liu, Y.; Jing, F.; Xu, Y.; Xie, Y.; Shi, F.; Fang, H.; Li, M.; Xu, W.
    Design, synthesis and biological activity of thiazolidine-4-carboxylic acid derivatives as novel influenza neuraminidase inhibitors (2011), Bioorg. Med. Chem., 19, 2342-2348.
    View publication on PubMed
Search for more literature for 3.2.1.18

Inhibitors

Inhibitors Comment Organism Structure
(4R)-2-(2-carboxyphenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-carboxyphenyl)-3-(chloroacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-carboxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-carboxyphenyl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-hydroxy-3-methoxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-hydroxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(2-nitrophenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(4-cyanophenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(4-cyanophenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(4-cyanophenyl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(furan-2-yl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(furan-2-yl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-(furan-2-yl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-2-phenyl-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-(chloroacetyl)-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-(chloroacetyl)-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-(chloroacetyl)-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-(chloroacetyl)-2-(4-cyanophenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-(chloroacetyl)-2-(furan-2-yl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-(chloroacetyl)-2-phenyl-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-glycyl-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-glycyl-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-glycyl-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
(4R)-3-glycyl-2-phenyl-1,3-thiazolidine-4-carboxylic acid
-
 influenza A virus
L-Cysteine hydrochloride
-
 influenza A virus
additional information design Influenza NA inhibitors that exhibit increased activity based on thiazolidine ring, evaluation of thiazolidine-4-carboxylic acid derivatives as Influenza neuraminidase inhibitors influenza A virus
oseltamivir carboxylate
-
 influenza A virus

Organism

Organism UniProt Comment Textmining
influenza A virus
-
-
-

Synonyms

Synonyms Comment Organism
neuraminidase
-
 influenza A virus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
 pH and temperature not specified in the publication influenza A virus oseltamivir carboxylate
0.00014
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-glycyl-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
0.00021
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-glycyl-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
0.00028
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-carboxyphenyl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
0.00053
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-glycyl-2-phenyl-1,3-thiazolidine-4-carboxylic acid
0.00065
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-hydroxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
0.00081
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(4-cyanophenyl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
0.00098
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(furan-2-yl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
0.00102
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-glycyl-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
0.00121
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-phenyl-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
0.00162
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-hydroxy-3-methoxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
0.00187
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-nitrophenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
0.00192
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-carboxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
0.00247
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(4-cyanophenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
0.00289
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(furan-2-yl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
0.00584
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-(chloroacetyl)-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
0.00753
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-(chloroacetyl)-2-phenyl-1,3-thiazolidine-4-carboxylic acid
0.00765
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-(chloroacetyl)-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
0.00792
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-(chloroacetyl)-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
0.00864
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-(chloroacetyl)-2-(4-cyanophenyl)-1,3-thiazolidine-4-carboxylic acid
0.0107
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-carboxyphenyl)-3-(chloroacetyl)-1,3-thiazolidine-4-carboxylic acid
0.0123
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
0.0129
-
 pH and temperature not specified in the publication influenza A virus (4R)-3-(chloroacetyl)-2-(furan-2-yl)-1,3-thiazolidine-4-carboxylic acid
0.0181
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-carboxyphenyl)-1,3-thiazolidine-4-carboxylic acid
0.0202
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
0.0213
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid
0.0225
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
0.0234
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(4-cyanophenyl)-1,3-thiazolidine-4-carboxylic acid
0.0431
-
 pH and temperature not specified in the publication influenza A virus (4R)-2-(furan-2-yl)-1,3-thiazolidine-4-carboxylic acid