Literature summary for 3.2.1.18 extracted from

Kim, S.; Oh, D.B.; Kang, H.A.; Kwon, O.
Features and applications of bacterial sialidases (2011), Appl. Microbiol. Biotechnol., 91, 1-15.

Search for more literature for 3.2.1.18

Cloned(Commentary)

Cloned (Comment)	Organism
gene TS1, DNA and amino acid sequence determination and analysis, sequence comparisons	Trypanosoma congolense

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma congolense	Q7YZT3	11 isozymes of trans-sialidase 1, gene TS1	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	nine potential N-glycosylation sites	Trypanosoma congolense

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	trans-sialidase 1 produces alpha2,3-sialyllactose from lactose by desialylating fetuin exhibiting transsialidase activity, substrate specificities for lactose, fetuin and synthetic substrates, overview. The enzyme is able to sialylate asialofetuin. Sialylation pattern of the N-glycans on fetuin catalyzed by the trans-sialidases, overview	Trypanosoma congolense	?	-	?

Subunits

Subunits	Comment	Organism
More	the enzyme possesses an N-terminal signal peptide and a catalytic domain, residues 17-467, which is connected through a long alpha helix, residues 468-491, to a lectin domain, residues 492-732, followed by a potential C-terminal GPI-anchor attachment site, residues 733-750	Trypanosoma congolense

Synonyms

Synonyms	Comment	Organism
trans-sialidase 1	-	Trypanosoma congolense

General Information

General Information	Comment	Organism
additional information	trans-sialidase 1 model structure complexed with the Sia derivative 3-fluoro-5-N-acetyl-9-benzamido-2,9-dideoxy-neuraminic acid	Trypanosoma congolense

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Release 2023.1 (January 2023)